and potentially, transformation. On the basis of striking cell type specificity of chromatin structure7,8, we hypothesized that assessment of open chromatin in bulk tumour cells with matched cells of origin would reveal novel epigenetic biomarkers of tumour cell of origin...
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and how 27 major features of the cell nucleus evolved in four logical stages, making both mechanisms and selective advantages explicit: two initial stages (origin of 30 nm chromatin fibres, enabling DNA compaction; and firmer attachment