Ageing of the immune system, or immunosenescence, contributes to the morbidity and mortality of the elderly1,2. To define the contribution of immune system ageing to organism ageing, here we selectively deleted Ercc1, which encodes a crucial DNA repair protein3,4, in mouse haematopoietic cells ...
J. Lymph node stromal cells: cartographers of the immune system. Nat. Immunol. 21, 369–380 (2020). Article CAS PubMed Google Scholar Takeda, A. et al. Single-cell survey of human lymphatics unveils marked endothelial cell heterogeneity and mechanisms of homing for neutrophils. Immunity 51...
We perform single-cell transcriptomes of 84,363 cells derived from 15 tissue organs of one adult donor and generate an adult human cell atlas. The adult human cell atlas depicts 252 subtypes of cells, including major cell types such as T, B, myeloid, epithelial, and stromal cells, as well...
For the past two decades, growing research has been pointing to multiple repercussions of bisphenol A (BPA) exposure to human health. BPA is a synthetic oestrogen which primarily targets the endocrine system; however, the compound also disturbs other systemic organ functions, in which the magnitude...
Taken together, old mouse DCs promoted age-specific alloimmune responses, accelerating the rejection of older organs. Moreover, increasing amounts of mt-DNA activated DCs in an age-specific fashion via TLR9. cf-mt-DNA from senescent cells accumulates with aging ...
By manual curation the network was found to consist of relevant functional clusters, such as coagulation, Kell blood group glycoprotein complex, haemoglobin and haem biosynthesis, inflammatory responses, immune regulation, and albumin-mediated transport. Our blood phosphoproteome is currently the largest ...
they were simply byproducts of skull development (Darwin1859); some formerly parasitic transposable elements in the genome, which had no function at the organism level, have been co-opted into a variety of other roles, such as in the vertebrate adaptive immune system (e.g., Zhou et al....
when it occurs systemically it can lead to immunosuppression as a result of the depletion of recirculating lymphocytes. Several mediators of the innate immune system are known to cause shutdown, including interferon α/β (IFN-α/β) and tumour necrosis factor2,3,4,5, but the mechanism has ...
Versions Notes Abstract Organ-on-a-chip technology has been used in testing small-molecule drugs for screening potential therapeutics and regulatory protocols. The technology is expected to boost the development of novel therapies and accelerate the discovery of drug combinations in the coming years. ...
they were simply byproducts of skull development (Darwin1859); some formerly parasitic transposable elements in the genome, which had no function at the organism level, have been co-opted into a variety of other roles, such as in the vertebrate adaptive immune system (e.g., Zhou et al....