during animal regeneration Xiaohui Jia1,2, Weifeng Lin1,3 and Wei Wang1,3* Open Access Abstract Activation of regeneration upon tissue damages requires the activation of many developmental genes responsible for cell proliferation, migration, differentiation, and tissue patterning...
Primarily, the epigenetic regulation via enzymes such as histone deacetylase (HDAC), histone methyltransferase (HMT), histone acetyltransferase (HAT) and histone demethylase (HDM) can result in interconversion of heterochromatin and euchromatin phases via acetylation and methylation reactions as shown in ...
aChromSTEM tomogram reconstructions for DMSO (left panel) and ActD treated (center panel) BJ fibroblasts. The domains radii for BJ cells treated ActD (right panel,n = 48 domains) show 1.25 times (unpaired two tail t-test,p = 0.002) increase compared to control (n = 71 domai...
Deregulation in another HMT, LSD1, promotes acute lymphoblastic leukemia (ALL) and AML [183,184]. Several LSD1 inhibitors (TCP, ORY-1001, GSK-2879552, and ORY-2001) are currently being evaluated for cancer treatment and have been shown to inhibit proliferation, differentiation, and invasion in...