Aza-heterocycles with rings of more than 6 members are underrepresented in medicinal chemistry owing to challenges with their synthesis. Now, the conversion of 5- and 6-membered saturated cyclic amines into 7- and 8-membered aza-heterocycles can be achieved via a ring expansion cascade reaction....
Despite decades of ground-breaking research in academia, organic synthesis is still a rate-limiting factor in drug-discovery projects. Here we present some current challenges in synthetic organic chemistry from the perspective of the pharmaceutical industry and highlight problematic steps that, if overco...
Functional group, any of numerous combinations of atoms that form parts of chemical molecules, that undergo characteristic reactions themselves, and that in many cases influence the reactivity of the remainder of each molecule. In organic chemistry the c
Material Type: Exam; Professor: Larock; Class: ORGANIC CHEMSTRY II; Subject: CHEMISTRY; University: Iowa State University; Term: Fall 2007; Typology: Exams Pre 2010 Report document Less info 20PointsDownload Uploaded on 09/02/2009 koofers-user-hyd 🇺🇸 10 documentsFollow ...
Providing vital knowledge on the design and synthesis of specific metal-organic framework (MOF) classes as well as their properties, this ready reference summarizes the state of the art in chemistry.Divided into four parts, the first begins with a basic introduction to typical cluster units or co...
Mercury in organic chemistry. 34. Synthesis of vinylmercurials via mercuration of propargylic amines Propargylic amines react readily with 1-2 M HgCl2 in 2-6 M HCl to precipitate the ammonium trichloromercurate, bis(ammonium) tetrachloromercurate, or bis (... RC Larock,LD Burns,S Varaprath,...
Organic and Medicinal chemistry international Journal is an open access journal that is committed to publish the papers on various topics of chemistry, especially synthetic organic chemistry, and pharmacology and various other biological specialties
Aza-heterocycles with rings of more than 6 members are underrepresented in medicinal chemistry owing to challenges with their synthesis. Now, the conversion of 5- and 6-membered saturated cyclic amines into 7- and 8-membered aza-heterocycles can be achieved via a ring expansion cascade reaction....
integrations of ~1:2 for Na-based half cells indicated that the PXZ units underwent two-step reaction in Na-based half cells. In K-based half cells, the oxidation process of PXZ units was one-step reaction while the reduction process was two-step reaction according to the integration of ~...
A computer-aided design (CAD)-based approach and sol-gel chemistry were used to design organic/inorganic hybrid materials, and multilayer dental post with uniform stress distribution was reported. It confirmed that computer-aided device design could help people to improve the performance of prosthesis...