148 Lactate and pyruvate are important energy substrates for spermatocytes and spermatids where they are more effective than glucose in promoting RNA and protein synthesis by these cells.149 Another important feature of Sertoli cells is their formation of a meshwork around developing germ cells. The ...
Muscle is the largest depot for glucose disposal and the storage of amino acids. Myokines derived from myocytes include IL-6, irisin, myostatin, and FGF-21 [77,97,98,106,112,113,114,115,116]. Muscle disuse and atrophy result in osteoporosis, a process that also involves IL-6 [117]. ...
Nutrients Currently, commonly used perfusates, such as Steen solu- tionTM and Organ Care System (OCS) perfusate, use glucose as the only energy resource. However, during NMP, organs are perfused at body temperature. Glucose alone is not sufficient for organ metabolism. To prolong NMP for ...
Empagliflozin, which was originally developed to treat diabetes, is a sodium-glucose transporter 2 (SGLT2) inhibitor [117]. The beneficial effects of Empagliflozin in chronic renal failure have gradually emerged in recent years, and it is hypothesized that empagliflozin may alleviate renal fibrosis ...
Glucose serves as a metabolic fuel for every organism, functioning as a primary source of energy for some organs such as the brain. Physiologicalblood glucoseconcentration is maintained in a narrow range with values averaging about 6mM except for variation during moments of food intake or activephys...
(I-BET151) on NASH and hepatic fibrosis. They found that I-BET151 treatment was able to maintain glucose homeostasis, reduce the expression of inflammatory genes in the interferon signaling pathway, and inhibit the expression ofTgf-β,Timp1and other fibrosis-related genes [219]. Rong Fu et ...
Despite the known role of the endocrine pancreas in glucose metabolism29, glucose metabolism was not significantly affected by thehsd17b12amutation (Supplementary Fig.2h). Thus, the loss ofhsd17b12aprimarily impacts the expansion of the exocrine pancreas and liver....
(I-BET151) on NASH and hepatic fibrosis. They found that I-BET151 treatment was able to maintain glucose homeostasis, reduce the expression of inflammatory genes in the interferon signaling pathway, and inhibit the expression ofTgf-β,Timp1and other fibrosis-related genes [219]. Rong Fu et ...
Formerly, several physiological roles of organokines, including adipokines, hepatokines, myokines and gut hormones have been described in obesity, especially in the regulation of glucose and lipid metabolism, insulin sensitivity, oxidative stress, and low-grade inflammation. The canonical effect of ...
for the ECM remodelling produced by mechanical damage (Li et al.2022b) (Table2). Tang and colleagues reported the potential therapeutic impact of punicalagin, also known as PUN (P2,3-hexahydroxydibenzoyl-gallagyl-D-glucose), on SUI following mechanical damage in mice. This process might also...