The present disclosure, the formula: [wherein: W, X and Y , Y , Y and Y are as defined herein] New compounds represented by and treating neurological disorders or mental disorders associated with orexin receptors, preventing, ameliorating, their use for reducing the control or at risk....
英文名称:Orexin receptor antagonist 2 用途:科研 纯度:98.00% CAS编号:1457940-75-8 产地:中国 品牌:Chemstan 包装规格:5 mg 货号:CS-136922 是否进口:否 Description Orexin receptor antagonist 2 (compound 30) is a potentorexin receptorantagonist withpKis of 7.69 and 9.78. Orexin receptor antagonist 2...
英文名: Orexin receptor antagonist 4描述: Orexin receptor antagonist 4 是有效的选择性食欲素 2 受体 (OX2R) 拮抗剂。Orexin receptor antagonist 4 抑制 OX2R 和 OX1R 的 IC50分别为 4.27 nM 和295 nM。存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year 化合物 Orexin ...
MCE 站:Orexin receptor antagonist 3 产品活性:Orexin receptor antagonist 3 (example 216) 是促食素受体 (orexin receptor) 的拮抗剂,信息来自 WO2011050198A1 的example 216。 研究领域:GPCR/G Protein | Neuronal Signaling 作用靶点:Orexin Receptor (OX Receptor) 相关产品:Bioactive Compound Library Plus | ...
A total of 30 mg kg−1 (per kg of body weight) of the dual orexin receptor antagonist ALMO (hydrochloride, MedChemExpress), 20 mg kg−1 of the orexin receptor-1 antagonist SB-334867 (cat. no. 1960, Tocris Bioscience) or 20 mg kg−1 of the orexin receptor-2 antag...
中文名称: OREXIN RECEPTOR ANTAGONIST 2 中文同义词: 英文名称: 2,9-Diazaspiro[5.5]undecan-1-one, 9-(4,6-dimethyl-2-pyrimidinyl)-2-[(5-methoxy-1H-indol-3-yl)methyl]- 英文同义词: 2,9-Diazaspiro[5.5]undecan-1-one, 9-(4,6-dimethyl-2-pyrimidinyl)-2-[(5-methoxy-1H-indol-3-yl)met...
(Orexin receptor antagonist 3) 英文名称: Orexin receptor antagonist 3 CAS No.: 1293282-55-9 分子式: C21H22N8O3 分子量: 434.451182842255 如需查看该化合物的详细结构式,mol文件,smile,InChi 请点击:Orexin receptor antagonist 3结构式 下载该化合物MOL文件: Orexin receptor antagonist 3MOL PubChem CID...
[4] Langmead, C. J. et al. Characterisation of the binding of [3H]-SB-674042, a novel nonpeptide antagonist, to the human orexin-1 receptor. British Journal of Pharmacology. 2004, 141, 340–346. [5] Chemelli, R. M. et ...
Moreover, administration of anti-orexin antibodies or an orexin receptor antagonist, reduced food intake (Sakurai and Mieda, 2011). Studies on human narcolepsy patients [orexin A and B are both associated with this disorder (Chapman, 2004)], show that orexins play a role in energy homeostasis...
SORA, single orexin receptor antagonist; DORA, dual orexin receptor antagonist. n.d., not determined. MK4305 is a compound 10 with a 7-methyl substitution on the diazepane core with a potent dual orexin receptor antagonistic activity. This compound is also currently under Phase III c...