The residues assigned to each color are indicated by the legend at left *, conserved residues. Full details of the alignment are shown in Supplementary Data S1. (b) Multiple alignment of the basic patch of eukaryotic Orc1 homologs, including representative model species. NCBI accession numbers ...
OurScORC·DNA complex structure is similar to the previous 3.0 Å model with few exceptions6: first, we observe only weak density for the winged-helix (WH) domain of Orc2, which is sandwiched between Orc1 and Orc2 in the earlier structure of the DNA-bound yeast initiator obtained from...
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(a) Multiple alignment of a BLAST search with ScOrc1201–420is shown on top using a colored rectangular pixel for each residue. A magnified alignment of the basic patch is shown below. The residues assigned to each color are indicated by the legend at left *, conserved residues. Full detai...