Combination treatment was assessed in vivo on 20 ESBL-EC urinary tract infection (UTI) patients. Results: ESBL-EC isolates were confirmed in 150 patients with a mean age of 46.67 years, 75.2% of them being women. Antibiotic susceptibility testing of isolates indicated high resistance rate to ...
This study aimed to evaluate the clinical and bacteriological effect of oral treatment with ceftibuten plus amoxicillin-clavulanic acid in patients with a urinary tract infection (UTI) caused by an extended-spectrum beta-lactamase (ESBL)-producing micro-organism. In this retrospective observational case...
ESBL-producing bac- teria often carry resistance to other antibiotic classes than beta-lactam antibiotics, for instance quinolones and trimethoprim-sulfamethoxazole (TMX), which are the mainstay oral treatment for febrile UTI [3]. This can result in longer treatment durations with intravenous ...
Most extended-spectrum β-lactamases (ESBLs) derive from this class, however, indicating that clavulanic acid is stable against these enzymes, which is why it is commonly used for in vitro detection of ESBL-producing bacteria. Susceptibility to amoxicillin versus amoxicillin–clavulanic acid: a ...
with a lower UTI. Single-dose fosfomycin trometamol was generally well tolerated, with gastrointestinal adverse events (e.g. diarrhoea, nausea) reported most commonly. In conclusion, single-dose fosfomycin trometamol is an important option for the first-line empirical treatment of uncomplicated lower ...
195. Intravenous to Oral Antibiotics Versus Intravenous Antibiotics: A Step-Up or a Step-Down for Extended Spectrum Beta-Lactamase Producing Urinary Tract Infections?BACKGROUND. The treatment of extended-spectrum beta-lactamase (ESBL)-producing urinary tract infections (UTI) may include either ...
Organisms producing CTX-M ESBLs have emerged rapidly in our community; many are recovered from outpatient urinary infections (UTI). Most isolates are resistant to TMP-SMX and fluoroquinolones, limiting outpatient treatment options. We examined several oral agents and one long-acting parenteral agent ...
This study aimed to evaluate the clinical and bacteriological effect of oral treatment with ceftibuten plus amoxicillin-clavulanic acid in patients with a urinary tract infection (UTI) caused by an extended-spectrum beta-lactamase (ESBL)-producing micro-organism. In this retrospective observational ...
CeftibutenESBL ProductionOutpatient Hospital CareClavulanic AcidPivmecillinamThis study aimed to evaluate the clinical and bacteriological effect of oral treatment with ceftibuten plus amoxicillin-clavulanic acid in patients with a urinary tract infection (UTI) caused by an......
Tebipenem (TBP) is an orally bioavailable carbapenem administered as a pro-drug (tebipenem pivoxil hydrobromide) with broad-spectrum activity that is currently in development for the treatment of patients with complicated UTI. Herein we describe a series of 7-day hollow-fiber in vitro infection ...