A clinical study of a long-acting oral steroid formulation, containing 2.0 mg quinestrol and 2.5 mg quingestanol acetate, was undertaken during a 31-month period. A total of 212 women were enrolled in the study and 2,781 women-months experience was accumulated. Life-table analysis of event...
EXE is a neutral compound with a steroid structure and high lipophilicity, yet it exhibits an unstable bioavailability of about 5 %. This is attributed to its poor solubility and high hydrophobicity, which restrict its application. Developing nanoscale formulations has emerged as a new approach ...
Oral infection with cysts is the main transmission route of Toxoplasma gondii (T. gondii), which leads to lethal intestinal inflammation. It has been widely recognized that T. gondii infection alters the composition and metabolism of the gut microbiota,
Table 5: Effect on Intragastric pH on Day 9 (N=25) Naproxen 500 mg combined with esomeprazole 10 mg 20 mg 30 mg % Time Gastric pH >4† 41.1 (3.0) 71.5 (3.0) 76.8 (3.0) Coefficient of variation 55% 18% 16% † Gastric pH was measured over a 24-hour period LS Mean ...
Scopoletin is an active coumarin possessing a variety of pharmacological activities, including anti-hyperuricemic effect, but with poor solubility. To improve its oral bioavailability, we attempted to encapsulate scopoletin into Soluplus micelles (Solupl
plantarum 299v were suggested to be expressed in adipocytes (Table S2). Except for FABP2, all down-regulated genes in the PPAR pathway were predicted to be expressed in adipocytes. PPARG itself and 9 out of the 20 genes associated with steroid metabolism were predicted to be expressed in ...
For Sco-PM, the solubility of scopo- letin increased slightly with increasing of Soluplus, mainly Table 1. Solubility of scopoletin, Sco-PM, and Sco-Ms in water at 25 °C. Data represent mean±SD. n=3. Scopoletin/ Soluplus (w/w) Sco-PM (mg/mL) Sco-Ms (mg/mL) 1:0 1:10 1...
Two or more mutations in the same patient were observed (Supplementary Table S6) in: TP53 (4/31; that is, 4 patients harboured Z2 mutations in TP53 among the 31 patients who harboured mutations in this gene), FAT1 (3/20), MLL4 (2/8) and NOTCH1 (1/8). Observed mutations in ...
This table includes all adverse events (whether considered by the investigator drug related or unrelated to drug) which occurred at an incidence rate of at least 3.0% in the albuterol sulfate inhalation aerosol group and more frequently in the albuterol sulfate inhalation aerosol group than in the...
There has been growing interest in the clinical importance of 11β-HSDs in that the 11β-HSD isozymes are thought to play a major role in the modulation of local cortisol levels and hence access of active steroid to corticosteroid receptors. The inherent form of hypertension, apparent mineralocor...