the 5-year survival rate of this aggressive cancer has not improved significantly over the past few years. The various inaccessible sites of OC and the high toxicity of current chemotherapeutic
Another factor contributing to the rise of inflammatory markers in advanced age seems to be a dysregulation of the immune system and immunosenescence. In addition to the increased percentage of late T effector cells, memory T cells (Varadhan et al.2014) myeloid cells and NK cells (Franceschi et...
A. Recent lessons learned from prevention and recent-onset type 1 diabetes immunotherapy trials. Diabetes 62, 9–17, doi: 10.2337/db12-0562 (2013). 2. Faria, A. M. & Weiner, H. L. Oral tolerance: therapeutic implications for autoimmune diseases. Clin Dev Immunol 13, 143–157, doi: ...
Mrsny RJ. Lessons from nature: ‘Pathogen-Mimetic’ systems for mucosal Nano-medicines. Adv Drug Deliv Rev. Elsevier B.V.; 2009;61:172–92. El-Feky GS, Zayed GM. PLGA nanoparticles loaded mucoadhesive and thermosensitive hydrogel as a potential platform for the treatment of oral mucositis. ...
Targeting epidermal growth factor receptor in head and neck cancer: lessons learned from cetuximab. Exp Biol Med (Maywood) 2010; 235: 907–920. Article CAS Google Scholar Kimura I, Kitahara H, Ooi K, Kato K, Noguchi N, Yoshizawa K et al. Loss of epidermal growth factor receptor ...
Targeting the estrogen receptor alpha (ERα) pathway is validated in the clinic as an effective means to treat ER+ breast cancers. Here we present the development of a VHL-targeting and orally bioavailable proteolysis-targeting chimera (PROTAC) degrader
Since December 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly resulted in a global pandemic with approximately 4 million deaths. Effective oral antiviral agents are urgently needed to treat coronavirus disease-2019 (COVID-19), block SARS-CoV-2 transmission, and prev...
Data regarding the demographic characteristics of the study sample were compiled for analysis using Chi Square, the recommended method for statistical comparisons of non-parametric, categorical data. In addition, the qPCR results were also categorized (HPV-positive, HPV-negative) and analyzed using Chi...
In recent years, however, advances in metagenomics have allowed for the detection and characterization of more and more native viral particles also residing in the human body, as well as animal systems with the potential for zoonotic transfer [2]. Zoonotic simply means that a pathogen was ...
Deep lessons learned: Radiology, oncology, pathology, and computer science experts unite around artificial intelligence to strive for earlier pancreatic cancer diagnosis. Diagn. Interv. Imaging 2020, 101, 111–115. [Google Scholar] [CrossRef] Weikert, T.; Cyriac, J.; Yang, S.; Nesic, I.; ...