Following unilateral renal IR surgery, C57BL/6J wild type (WT) mice were administered B12 via drinking water at a dose of 50mg/L. After 5 days of the treatment, plasma B12 levels increased by 1.2-1.5x, and kidney B12 levels increased by 7-8x. IRI mice treated with B12 showed near ...
Oral Cyanocobalamin Supplementation in Older People With Vitamin B12 Deficiency: A Dose-Finding Trial Supplementation with high doses of oral cobalamin is as effective as cobalamin administered by intramuscular injection to correct plasma markers of vitamin... SJPM Eussen,Lisette C P G M de Groot,...
High dose oral vitamin b12 for the treatment of vitamin b12 deficiency anemiadoi:10.1046/j.1523-5408.2000.00030-7.xPamela FanarasMaria A. SummaJohn Wiley & Sons, Ltd.Nutrition in Clinical Care
et al. Use of a population pharmacokinetic approach for the clinical development of a fixed-dose subcutaneous formulation of trastuzumab. CPT Pharmacometrics Syst. Pharmacol. 3, e87 (2014). CAS Google Scholar Shah, R. B., Patel, M., Maahs, D. M. & Shah, V. N. Insulin delivery ...
Oral manifestations of vitamin B12 deficiency may be isolated and represent the first signs of this deficiency. Initially, they are discreet, proteiform, fleeting but recurrent. They must be recognized at this stage because the classica
CONCLUSION: Switching patients with vitamin B12 deficiency from intramuscular to high-dose oral therapy and treating patients newly diagnosed with vitamin B12 deficiency with oral vitamin B12 from the outset could save resources in the medium and long term, and in newly diagnosed patients. Savings ...
The oral administration of vitamin B12 offers a potentially simpler and cheaper alternative to parenteral administration, but its effectiveness has not been definitively demonstrated. The following protocol was designed to compare the effectiveness of orally and intramuscularly administered vitamin B12 in the...
Different oral treatment regimens were used; the daily dose of B12 used ranged from 0.004 to 3 mg, with 1 mg daily being the most used dose (in 53 patients, 69.7%). Fifty-nine patients (77.6%) were treated with doses of oral B12 ≥1 mg/day. There were no significant differences in...
(Medicine) the extent to which a drug or other substance is taken up by a specific tissue or organ after administration; the proportion of the dose of a drug that reaches the systemic circulation intact after administration by a route other than intravenous. Also called:systemic availability ...
Oral vitamin B12 and high-dose folic acid in hemodialysis patients with hyper-homocyst(e)inemia. Kidney Int. 2001;59(3):1103-1109.Manns B, Hyndman E, Burgess E, et al. Oral vitamin B12 and high-dose folic acid in hemodialysis patients with hyper-homocyst(e)inemia. Kidney Int 2001;59:...