Injectable vs oral B12doi:https://doi.org/10.1136/bmj.c2305BMJ
C. et al. Comparing the efficacy and tolerability of a new daily oral vitamin B12 formulation and intermittent intramuscular vitamin B12 in normalizing low cobalamin levels: a randomized, open-label, parallel-group study. Clin. Ther. 33, 358–371.e2 (2011). CAS Google Scholar Emisphere. ...
severe breathing problems (such as obstructive lung disease, severe asthma), blood problems (such as anemia, vitamin B12 deficiency), kidney disease, liver disease.Before having surgery or any X-ray/scanning procedure using injectable iodinated contrast material, tell your doctor that you are taking...
Decreased vitamin B12 levels and abnormal Schilling’s tests have been observed in some patients receiving octreotide. Monitor vitamin B12 levels during treatment with MYCAPSSA. Patient Counseling Information Advise the patient to read the FDA-approved patient labeling (PATIENT INFORMATION). ...
Throughout history, oral administration has been regarded as the most convenient mode of drug delivery, as it requires minimal expertise and invasiveness. Although oral delivery works well for small-molecule drugs, oral delivery of macromolecules (partic
Successful application of SNAC was first demonstrated by the approval of an oral formulation of vitamin B12 (cyanocobalamin/SNAC) in 2014 by the US FDA, albeit as a medical food [43,48,49]. As part of the approval process, SNAC was assigned generally regarded as safe (GRAS) status by ...
Low permeability might be acceptable if a safe and consistent therapeutic effect can be achieved with a molecule that has a long t1/2, even in the context of high variability in BA, otherwise poorly permeable drugs are typically formulated in injectable dosage forms or in dosage forms using ...
Vitamin B12 functionalized layer by layer calcium phosphate nanoparticles: A mucoadhesive and pH responsive carrier for improved oral delivery of insulin. Acta Biomater. 2016, 31, 288–300. [CrossRef] [PubMed] 29. Liu, H.; Wang, Y.; Wang, M.; Xiao, J.; Cheng, Y. Fluorinated poly(...
dehydration of dicalcium phosphate dihydrate (named brushite, DCPD, CaHPO4·2H2O) using solvent-based methods or external energy-assisted processing.34Its main application is as bone cement; however, it can be applied as a coating on metallic implants, granules, injectable pastes, and scaffolds....