In essence, a strong unmet need for oral antibiotics, active against extended-spectrum β-lactamase (ESBL) uropathogens has emerged. Oral carbapenems (tebipenem and sulopenem) and oral cephalosporin/β-lactamase inhibitor combinations are in various stages of clinical development for the treatment of ...
Beta-lactam antibiotics were used for 86% of oral treatment courses. Outcomes between EOS and IV-only treatment were similar. Among the 81 of 84 EOS and 16 of 16 IV-only patients, no deaths attributable to SaB occurred within 90 days. SaB recurred in 3 (4%) of the EOS and 1 of ...
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Heikkinen ° (Turku, FI) Acute otitis media (AOM) is generally considered a bacterial infection that is treated with antibiotics. However, despite extensive use of broad- spectrum antibiotics for this condition, the clinical response to the treatment is often poor. This fact, together with vast...
penicillin-sensitive patients, caution should be exercised because cross hypersensitivity among beta-lactam antibiotics has been clearly documented and may occur in up to 10% of patients with a history of penicillin allergy. If an allergic reaction to Cefixime for oral suspension occurs, discontinue ...
All the patients with one exception had length of hospital stay greater than 21 days and needed mechanical ventilation; all the newborns used central catheters, parenteral nutrition and broad-spectrum antibiotics. Among the 84 patients with confirmed sepsis, 36 (43%) died and their blood cultures...
Fosfomycin trometamol (fosfomycin tromethamine) [Monuril®, Monurol®, Monural®] is approved in numerous countries worldwide, mainly for the treatment of uncomplicated urinary tract infections (UTIs). Fosfomycin has good in vitro activity against common uropathogens, such as Escherichia coli (inc...
195. Intravenous to Oral Antibiotics Versus Intravenous Antibiotics: A Step-Up or a Step-Down for Extended Spectrum Beta-Lactamase Producing Urinary Tract Infections?BACKGROUND. The treatment of extended-spectrum beta-lactamase (ESBL)-producing urinary tract infections (UTI) may include either ...
2011. Oral antibiotics for infections due to multidrug-resistant Gram- negative organisms. Scand. J. Infect. Dis. 43:649 - 651.Glasser JS, Markelz AE, Zera WC, Beckius ML, Mende K, Murray CK. 2011. Oral antibiotics for infections due to multidrug-resistant Gram-negative...
Bacteria harbouring extended-spectrum β-lactamases (ESBLs), derived by mutation from TEM-1, TEM-2 or SHV-1 β-lactamases, have been described world-wide. The in vitro activities of these enzymes against β-lactam antibiotics, including oral cephalosporins, are well recognised. The aim of ...