In general, the oral administration of drugs is patient convenient and practical and is preferred for many reasons. Patients are able to take the oral medication themselves, there is no need for expensive and frequent hospitalization or the discomfort of an injection which is associated with the ...
A device, pre-loaded with a drug, is insertible into a mouth of a patient or user having gums. Upon action of the gums with the device, the pre-loaded drug is dispensed. In an embodiment with an internal reservoir, the drug is released through holes and delivered into the mouth. In ...
The method is exemplified for chronically treating mice with Rimonabant, but can also be applied to many other drugs, as well as oral glucose tolerance test.doi:10.1038/protex.2011.236Lei ZhangProtocol ExchangeL. Zhang, Voluntary Oral Administration of Drugs in Mice, Protoc. Exch. Nat. Publ. ...
A sustained-release composition for oral administration of a drug, comprising the drug, a mixture of sodium alginate and xanthan gum as a carrier for sustained release and a mixture of hydroxypropyl m
Both drugs were administered as a single dose or co-administered with an oral dose of the CYP3A4 inhibitor ritonavir (12.5 mg kg À 1), the P-gp inhibitor elacridar (25 mg kg À 1) or both. Data are compared with previously reported data after oral administration of paclitaxel (...
Pentachlorophenol (PCP) was monitored for transcriptome responses in adult mouse liver at 2, 4, 8 and 24 hr after a single oral administration at four dose levels, 0, 10, 30 and 100 mg/kg. The expression data obtained using Affymetrix GeneChip MOE430 2.0 were absolutized by the Percellome...
Local administration of ibandronate and bone morphogenetic protein-2 after ischemic osteonecrosis of the immature femoral head: a combined therapy that sti... Bisphosphonate therapy has been shown to preserve the osteonecrotic femoral head in experimental and short-term clinical studies. However, a lack...
Administration A patient who misses a dose of BRILINTA should take one tablet (their next dose) at its scheduled time. For patients who are unable to swallow tablets whole, BRILINTA tablets can be crushed, mixed with water and drunk. The mixture can also be administered via a nasogastric tube...
PG01037 on Food–Cocaine Choice in Dominant and Subordinate Monkeys A subset of monkeys was also tested with the DA D3 receptor antagonist PG01037. On average, i.v. administration of PG01037 decreased cocaine choice in monkeys in whom i.v. Figure 5 Effects of intravenous and oral ...
administration. One animal was used at each sampling point. The number of animals at each time point was set to consider reproducibility [n = 3 (0.5, 8 and 24 hours) or n = 6 (1, 3, and 6 hours)]. Synovial tissues and cartilage were washed with saline to remove ...