尽管帕金森氏征的多发于65 岁以上,但是约有 5%~10%的患者在 40 岁以下被诊断出患有早发型帕金森氏征(early-onset Parkinson disease)。早发型帕金森氏征患者又被分为发病年龄在 21～40 岁的青年型帕金森氏征征(young-onset Parkinsons disease, YOPD)和发病年龄在 21 岁以下...
论坛导读:帕金森病(Parkinson’s disease)是全球第二大神经退行性疾病,其主要病理改变是黑质致密部多巴胺能神经元进行性丢失,从而导致运动症状的出现,如运动迟缓、静止性震颤等;而疾病中大脑其他区域的病变则导致了非运动症状,如嗅觉障碍、精神症状等。单基因突变可导致PD...
The discoveries of mutations in SNCA were seminal findings that resulted in the knowledge that α-synuclein is the major component of Parkinson's disease-associated Lewy bodies. Since the pathologic roles of these protein inclusions and SNCA mutations are not completely established, we characterized ...
L'hémochromatose héréditaire est causée par une mutation génétique et peut entraîner des maladies du foie et du cœur ; de nouvelles découvertes suggèrent qu'elle constitue également un facteur de risque pour des maladies comme la maladie de Parkinson. bionity.com La marque fémin...
[17] Vanqua Bio Announces First Patient Dosed in Phase 1 Clinical Trial Evaluating VQ-101, its Small Molecule GCase Activator for GBA-Parkinson’s Disease and Related Disorders. Retrieved April 9, 2024, from https://www.globenewswire.com/news-release/2024/04/09/2859875/0/en/Vanqua-Bio-Ann...
[4]Picillo, M., Palladino, R., Erro, R., et al. The PRIAMO study: active sexual life is associated with better motor and non‐motor outcomes in men with early Parkinson's disease. Eur J Neurol. 2019. 本文首发:医学界神经病学频道 ...
Gao, Ge, et al. “Dysregulation of Mitochondrial α-Ketoglutarate Dehydrogenase Leads to Elevated Lipid Peroxidation in CHCHD2-Linked Parkinson’s Disease Models.” Nature Communications, vol. 16, no. 1, Feb. 2025, p. 1982. www.nature.com, https://doi.org/10.1038/s41467-025-57142-9 ...
鱼是每家每户常见的家常菜,加上吃饭时喜欢聊天、看电视等,分散了注意力,导致鱼刺卡喉的意外每天都有发生。而被鱼刺卡了后,绝大多数人会嫌麻烦,只要扛得过去,一般不愿意去医院。前几天,杭州有位中年男子因鱼刺卡喉,导致喉头严重水肿,睡到半夜因喉头水肿导致严重窒息。虽经多天抢救,依然没能...
1、Trivedi DK, Sinclair E, Xu Y, et al. Discovery of Volatile Biomarkers of Parkinson's Disease from Sebum. ACS Cent Sci. 2019;5(4):599-606. doi:10.1021/acscentsci.8b00879 2、Sinclair E, Trivedi DK, Sarkar D, et al. Metabolomics of sebum reveals lipid dysregulation in Parkinson's ...
1、Trivedi DK, Sinclair E, Xu Y, et al. Discovery of Volatile Biomarkers of Parkinson's Disease from Sebum. ACS Cent Sci. 2019;5(4):599-606. doi:10.1021/acscentsci.8b00879 2、Sinclair E, Trivedi DK, Sarkar D, et al. Metabolomics of sebum reveals lipid dysregulation in Parkinson's ...