Lipid nanoparticles (LNPs) for the efficient delivery of drugs need to be designed for the particular administration route and type of drug. Here we report the design of LNPs for the efficient delivery of therapeutic RNAs to the lung via nebulization. We
Characterization of saRNA lipid nanoparticle formulations.aSchematic of saRNA formulated on the interior or exterior of the lipid nanoparticles, with ionizable (C12-200) or cationic (DDA, DOTAP) complexing lipids.bParticle diameter (in nm) as determined by Nanoparticle tracking analysis (NTA) (bar ...
Optimization of Lipid Nanoparticles and siRNA Conjugates for Enablement of siRNA Therapeutics.An abstract of the article "Optimization of Lipid Nanoparticles and siRNA Conjugates for Enablement of siRNA Therapeutics" by Vasant Jadhav is presented.
Optimization of Lipid Nanoparticles for Intramuscular Administration of mRNA Vaccines Author links open overlay panelKimberly J. Hassett 1, Kerry E. Benenato 1, Eric Jacquinet 1, Aisha Lee 1, Angela Woods 1, Olga Yuzhakov 1, Sunny Himansu 1, Jessica Deterling 1, Benjamin M. Geilich 1, ...
Intracellular delivery of messenger RNA (mRNA) has the potential to induce protein production for many therapeutic applications. Although lipid nanoparticles have shown considerable promise for the delivery of small interfering RNAs (siRNA), their utility as agents for mRNA delivery has only recently bee...
Indinavir binds completely to lipid at pH 7.4 regardless of lipid characteristic tested, but it is reversed at pH 5.5 or lower. The study suggests that indinavir nanoparticles composed of disteroyl phosphatidylcholine and methyl polyethylene glycoldisteroyl phosphatidyle...
The aim of the present study was to develop, characterize and optimize a solid lipid nanoparticle system to deliver budesonide to the lungs. Budesonide-loaded solid lipid nanoparticles were prepared by the emulsification-solvent diffusion method. The impact of various processing variables including ...
The efficacy of mRNA-based vaccines and therapies relies on lipid nanoparticles (LNPs) as carriers to deliver mRNA into cells. The chemical structure of ionizable lipids (ILs) within LNPs is crucial in determining their delivery efficiency. In this study
Ionizable lipids largely determine the biocompatibility of lipid nanoparticles (LNPs) and the efficacy for mRNA delivery. Rational design and combinatorial synthesis have led to the development of potent and biodegradable ionizable lipids, yet methodologies for the stepwise optimization of ionizable lipid...
Design and evaluation of polymer coated carvedilol loaded solid lipid nanoparticles to improve the oral bioavailability: A novel strategy to avoid intraduo... Solid lipid nanoparticles are most promising delivery systems for the enhancement of bioavailability of highly lipophilic drugs those prone to the...