State Key Laboratory of Experimental HematologyPLoS ONELi Y., Pal R., Sung L.-Y., Feng H., Miao W., Cheng S.-Y., Tian C., Cheng T. 2012. An opposite effect of the CDK inhibitor, p18(INK4c) on embryonic stem cells compared with tumor and adult stem cells. PLoS ONE 7, e4...
ain a water tunnel to simulate (1) circumferential flow induced by asymmetric inhibitor stub in the port of the RSRM, (2) vortex formation in the aft-dome cavity with and without nozzle vectoring. 正在翻译,请等待... [translate] ahrvatskih.dinara hrvatskih.dinara[translate] ...
Roles of DNA Fragmentation Factor and Poly(ADP-ribose) Polymerase-1 in Sensitization of Fibroblasts to Tumor Necrosis Factor-Induced Apoptosis DNA fragmentation factor (DFF) comprises DFF45 and DFF40 subunits, the former of which acts as an inhibitor of the latter (the catalytic subunit) and whos...
Our results indicated that the replication of the HCV subreplicon was suppressed via a decrease in autophagosome formation caused by the autophagy inhibitor 3MA, but enhanced via dysfunction in the lysosomal degradation caused by another autophagy inhibitor CQ. Human ATG10, a canonical isoform in ...
a The cell model includes (i) an active force-generating contractile element representing myosin motors, (ii) the actin filament network, (iii) the microtubule network, and (iv) two elements of the vimentin intermediate filament network. b The first vimentin element laterally reinforces and stabil...
Frequent promoter hypermethylation of Wnt pathway inhibitor genes in malignant astrocytic gliomas. Int J Cancer 2010, 126: 2584–2593. PubMed Google Scholar Polakis P. The oncogenic activation of beta-catenin. Curr Opin Genet Dev 1999, 9: 15–21. Article PubMed CAS Google Scholar Kim SA, ...
VM samples were mechanically homogenized in lysis buffer (10 mM Tris–HCl (pH 6.8), 2% SDS, and a cocktail protease inhibitor (Roche)). The protein concentrations of the tissue samples were measured using BCA protein assay kit (Pierce, USA). Equal amounts of protein (10–50 mg) were ...
The graph shows the mean (−SD) of 3 experiments, with at least 100 cells per condition per experiment. (B and C) Effect of altering the phosphatase at KNL1 on SAC phenotypes. (B) KNL1-MELT dephosphorylation in nocodazole-arrested cells treated with the MPS1 inhibitor AZ-3146 (2.5 μ...
For MDA-MB-231 cells, the Cer concentration was reduced by TNF-α, which could be prevent- ed when SPHK1 inhibitor dimethylsphingosine (DMS, 10 μmol/L) added. DMS could reverse the TNF-α induced increase of proliferation in MDA-MB-231 cells. Moreover, pretreatment of DMS could ...
The functional domains of ASXL1 and ASXL2 are shown in Fig. 1A. Whereas both proteins contain nuclear receptor-binding motifs, only ASXL1 harbors an HP1-binding motif. This motif is critical for retinoic acid receptor repression (28), and the ASXL1ΔHP1 mutant, which lacks this motif, ...