NLRP3 (NALP3, Cryopyrin) facilitates in vivo caspase-1 activation, necrosis, and HMGB1 release via inflammasome-dependent and -independent pathways. J Immunol 2009; 183: 2008–2015. 40. Satoh T, Kambe N, Matsue H. NLRP3 activation induces ASC-dependent programmed necrotic cell death, which ...
Performance will degrade if you select a large set of genes—either by selecting multiple pathways, large gene-sets or many ad-hoc gene selections. The more genes selected the more likely it is that the query performance degrades, especially with large result datasets. 3-8 Oracle Healthcare ...
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