Functional expression of opioidreceptor-like receptor and its endogenous specific agonistnociceptin/orphanin FQ during m ouse em bryogenesis. Wu YL,Fan GH,Zhao J,et al. Cell Research . 1997Wu Y L et al. Functional expression of opioid receptor-like receptor and its endogenous specific agonist ...
In this study we have explored a role for ECE2 in endocytic processing of 未 opioid peptides and its effect on modulating 未 opioid receptor function by using selective inhibitors of ECE2 that we had identified previously by homology modeling and virtual screening of a library of small ...
The effects of a particular opioid are determined by the extent of its interaction with the different types of opioid receptors, that is, what types of receptors it acts on and to what extent it activates the specific receptor types with which it interacts. Many opiates, including morphine,mepe...
The dynorphin/κ-opioid receptor system has been implicated in the pathogenesis and pathophysiology of several psychiatric disorders. In the present review, we present evidence indicating a key role for this system in modulating neurotransmission in brain circuits that subserve mood, motivation, and cog...
Neurons expressing this receptor therefore represent pharmacological entry points for brain adaptations to opioids. Comparison of studies reviewed here with MOR brain distribution (assessed using ligand autoradiography [114,115,116,117,118,119]; Fig. 3C) indicates that: (i) MOR is highly expressed ...
The results presented here suggest that these associations are probably related to the lower receptor availability of m-opioid receptors in G-allele carriers, as described above, but not to effects on presynaptic endogenous opioid function, since A118G showed no association with pain-induced ...
Toouli J. Sphincter of Oddi: function, dysfunction, and its management. J Gastroenterol Hepatol 2009 Oct; 24 Suppl. 3: S57-62 Google Scholar Penagini R, Bartesaghi B, Zannini P, et al. Lower oesophageal sphincter hypersensitivity to opioid receptor stimulation in patients with idiopathic achalas...
Symproic met its primary and key secondary endpoints in both COMPOSE I and II. Learn more: Side effects with Symproic (in more detail) Entereg Entereg (alvimopan) is a peripherally-acting mu opioid receptor antagonist used to help patients regain gastrointestinal (GI) function earlier ...
To investigate the contribution of the kappa-opioid receptor (KOR) to opioid function in vivo, we have generated KOR-deficient mice by gene targeting. We show that absence of KOR does not modify expression of the other components of the opioid system, and behavioural tests indicate that ...
Biological function of GABAA/benzodiazepine receptor heterogeneity. gamma-Aminobutyric acid (GABA) is the most prominent of the inhibiting neurotransmitters in the brain. It exerts its main action through GABAA receptors. The receptors respond to the presence of GABA by the opening of an intrinsic ani...