Filizola and co-workers have applied a combination of long-time molecular dynamics and oscillating chemical potential grand canonical Monte Carlo/molecular dynamics to investigate the distribution of Mg2+ and Nathorn in the m-opioid receptor and their impact on its function. Results indicate atomic ...
The effects of a particular opioid are determined by the extent of its interaction with the different types of opioid receptors, that is, what types of receptors it acts on and to what extent it activates the specific receptor types with which it interacts. Many opiates, including morphine,mepe...
DPI-125 exhibited a high respiratory safety profile, clearly related to its high δ-receptor potency. The ratio of the EC50 potencies for the μ- and δ-receptors was found to be positively correlated with the respiratory safety ratio. DPI-125 has similar potencies for μ- and κ-receptors...
Neurons expressing this receptor therefore represent pharmacological entry points for brain adaptations to opioids. Comparison of studies reviewed here with MOR brain distribution (assessed using ligand autoradiography [114,115,116,117,118,119]; Fig. 3C) indicates that: (i) MOR is highly expressed ...
Ambo A, Kohara H, Kawano S, Sasaki Y (2007) Opioid receptor-like 1 (ORL1) receptor binding and the biological properties of Ac-Arg-Tyr-Tyr-Arg-Ile-Arg-NH 2 and its analogs. J Pept Sci 13:672A. Ambo, H. Kohara, S. Kawano, Y. Sasaki, Opioid receptor-like1 (ORL 1) receptor ...
G-protein-biased agonism of the mu-opioid receptor (μ-OR) is emerging as a promising strategy in analgesia. A deep understanding of how biased agonist
are not ideal because only a fraction of patients achieve remission. Tianeptine is an effective antidepressant with a previously unknown mechanism of action. We recently reported that tianeptine is a full agonist at the mu opioid receptor (MOR). Here we demonstrate that the acute and chronic antid...
sense organ,sensory receptor lateral line,lateral line organ- sense organs of fish and amphibians; believed to detect pressure changes in the water organ- a fully differentiated structural and functional unit in an animal that is specialized for some particular function ...
Alternatively, transfer to methadone could be an option to treat patients with resistant complex chronic pain syndrome. Its pharmacological profile combines opioid, ketamine-like (NMDA receptor antagonist) and aminergic activities, which can be effective for different types of pain [108,109]. In any...
3) opioid receptor 阿片受体 1. The function of C-terminal tail of opioid receptors and the proteins interaction with C-terminal tail of opioid receptors; 阿片受体C-末端的功能及与其相互作用蛋白的研究进展 2. Role of opioid receptors in cerebral ischemic tolerance induced by electroacupuncture ...