中文名称: OPC-167832 英文名称: OPC-167832 CAS号: 1883747-71-4 品牌: TargetMol 产地: 美国 保存条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. 产品类别: 抑制剂 货号: T37880 ...
OPC-167832 (oral administration; 0.625-10 mg/kg; 4 weeks) significantly reduces lung CFU compared to the vehicle group. The dose-dependent decrease of lung CFU is observed from 0.625 mg/kg to 2.5 mg/kg. In a M. tuberculosis Kurono-infected ICR female mice model. OPC-167832 combin...
In summary, these results suggest that OPC-167832 is a novel and potent anti-TB agent, and regimens containing OPC-167832 and new or repurposed anti-TB drugs may have the potential to shorten the duration of treatment for TB. 展开 关键词: DprE1 inhibitor OPC-167832 antituberculosis agent ...
OPC-167832详情 评价(0) 货号: ajcx35074 CAS: 1883747-71-4 别名: OPC-167832 分子式: C21H20ClF3N2O4 分子量: 456.84 纯度: >98% 溶解度: DMSO : 180 mg/mL (394.01 mM; Need ultrasonic) 储存: Store at -20°C 库存: 现货 Background OPC-167832 is a potent and orally act...
In 2017, Otsuka completed a phase 1, single-ascending-dose study of OPC-167832. OPC-167832 is also being evaluated in pre-clinical studies using the hollow fiber system at the Baylor Scott & White Research Institute and in additional non-clinical studies in collaboration with the U.S. Nation...
Quabodepistat (OPC-167832), a Novel Antituberculosis Drug Candidate: Enhancing Oral Bioavailability via Cocrystallization and Mechanistic Analysis of ... Nasa Sakamoto,Kenichi Miyata,Toshiro Fukami 被引量: 0发表: 0年 Quabodepistat (OPC-167832), a Novel Antituberculosis Drug Candidate: Enhancing ...