OP9-DL1 and OP9-DL4 were originally derived from the OP9 mouse bone marrow stromal cell line, which was transduced to ectopically express Delta-like 1 or 4 proteins, respectively. OP9-DL cells mimic the thymic microenvironment in that when cocultured with mouse or human (h) HSCs, they ...
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其中,Not ch1 受体与配体分子 DL1 或DL4 的相互作用是 T 细胞定向分化所必需的[2]。Not ch 配体和受体在 T 细胞发育所必需的胸腺基质细胞中有大量表达,而 OP9 等骨髓来源的基质细胞尽管都具有支持 B 细胞发育的功能,但均不能诱导 T 细胞的分化,因此有学者推断这类骨髓基质细胞缺乏 T 细胞分化发育所必需的...
However, TGF-β1 treatment dose-dependently attenuated the increases in PPARγ and FABP4 expression induced by rosiglitazone in OP9-DL1 cells (Fig. 2b). Furthermore, the effects of TGF-β inhibitor LY-364947 on lipid accumulation in OP9-DL1 cells were also evaluated by Oil Red O staining....