Asthma‐like symptoms (ALS) often occur among children with lower respiratory tract infections (LRTIs). We aimed to determine the potential risk factors for ALS onset in LRTIs children.doi:10.1002/jcla.23227John Wiley & Sons, LtdJournal of Clinical Laboratory Analysis...
Chemogenetics rescues the health of the molecular network (pink) that surrounds neurons (green) in laboratory models. Scientists used the technique to delay the onset of ALS symptoms. Credit: University of Toronto A team of researchers led by scientists at the University of Toronto (U of T) h...
then handedness might be expected to influence the side of upper limb-onset disease and footedness likewise in lower limb-onset ALS.MethodsALS patients registered with an internet-based support site were invited to complete an online questionnaire concerning site of onset of symptoms and their domin...
DNA/RNA helicase gene mutations in a form of juvenile amyotrophic lateral sclerosis (ALS4). Individuals affected with ALS4 usually have an onset of symptoms at age <25 years, a slow rate of progression, and a normal life span. The ALS4 ... YZ Chen,CL Bennett,HM Huynh,... - 《Americ...
Hoping to stopneuron deathin ALS just as they did in Huntington's, the research team treated mice bred to have an ALS-like disease with injections of melatonin or with a placebo. Compared to untreated animals, the melatonin group developed symptoms later, survived longer, and had less degenera...
A total of 202 patients were diagnosed and stratified according to the onset of ALS symptoms (bulbar onset [BO] and limb onset [LO]). We noted the type of physician first seen by the patient. The diagnostic interval was calculated as the time between onset of symptoms and the final ...
- 《Journal of Alzheimers Disease Jad》 被引量: 10发表: 2015年 Supporting communication for patients with neurodegenerative disease. depending on whether their condition primarily affects speech and motor skills (ALS), language (primary progressive aphasia) or cognition (Alzheimer's disease... Melanie...
and SPG7 genes in Pt2, due to the presence of spastic tetraparaparesis; in the HTT gene in Pt1, due to the subtle onset of symptoms consistent with an affective disorder, together with cognitive dysfunction; and in the UBQLN2 and C9orf72 genes, recently associated to ALS/FTD, in both...
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that affects motor neurons resulting in severe neurological symptoms. Previous findings of our lab suggested that the axonal guidance tyrosine-kinase receptor EphA4 is an ALS disease-modifying gene. Reduction of EphA4 from developmental ...
While the SOD1G93A mouse model has been widely used in ALS research primarily due to rapid progression of symptoms [30], such early onset of disease may not represent the impact of age-related immunological changes as they appear in humans. The CD4 T-cell subsets are critical mediators of ...