Chemistry of Natural CompoundsLi, Y.L.; Wang, J.F.; He, W.J.; Lin, X.P.; Zhou, X.J.; Liu, Y.H. One Strain-many compounds method for production of polyketide metabolites using the sponge-derived fungus Arthrinium arundinis ZSDS1-F3. Chem. Nat. Compd. 2017, 53, 373-374. [...
一株菌多种次级代谢产物(One strain many compounds, OSMAC)策略作为一种简便有效的研究手段,已成功应用于该领域的研究。本文综述了OSMAC策略中常用的研究手段(包括改变培养状态、混合培养及添加酶抑制剂等),以及OSMAC与基因组扫描技术相结合的研究进展,并介绍了本研究室利用此方法对高产细胞松弛素的海洋来源真菌曲...
The OSMAC (One Strain Many Compounds) strategy has been a simple and effective approach to activate new metabolic pathways, and consequently the synthesis ... RR Ferreira,JS Cruz,L Hamerski - 《Revista Virtual De Química》 被引量: 0发表: 2022年 Functional-invariant solutions of the wave equ...
On the basis of the OSMAC (one strain many compounds) strategy, 14 indole diketopiperazine (DKP) alkaloids, including spirotryprostatins (1-3), tryprostatins (4-6), and cyclotryprostatins (7-14), were isolated from the endophyte Aspergillus fumigatus associated with Melia azedarach L. Their...
2019, Frontiers in Microbiology Multiple siderophores: bug or feature? 2018, Journal of Biological Inorganic Chemistry Extending the “one strain many compounds” (OSMAC) principle to marine microorganisms 2018, Marine Drugs View all citing articles on Scopus 2 Lead Contact ...
One Scaffold, Many Possibilities – Copper(I)‐Catalyzed Azide–Alkyne Cycloadditions, Strain‐Promoted Azide–Alkyne Cycloadditions, and Maleimide–Thiol Coupling of Ruthenium(II) Polypyridyl ComplexesOne Scaffold, Many Possibilities – Copper(I)‐Catalyzed Azide–Alkyne Cycloadditions, Strain‐Promoted Az...
compounds4a-gand5a-dwere synthesized by the reaction of intermediates3a-gwith thiolactic acid and thioglycolic acid by stirring at room temperature for 16–20 h in the presence of catalytic amount of anhydrous zinc chloride and 1–4 dioxane. Structures of all the synthesized compounds were ...
Dr. Christopher Ross has tested several compounds shown to slow the progression of Huntington’s in mice. Now he wants to test them in people who are positive for the Huntington’s mutation but have not developed symptoms—a novel approach to clinical drug trials, which almost always involve ...
Although many examples of the reaction of hydrazines with 1,4-dicarbonyl compounds have been published the reaction of 1-benzyl 6-methyl (2S)-2-{[(benzyloxy)carbonyl]amino}-4-oxohexanedioate with hydrazines is worth mentioning as benzylN-[(benzyloxy)carbonyl]-3-(5-oxo-4,5-dihydro-1H-pyr...
@wyeth.com Received: 22 June 2007 / Accepted: 8 July 2007 / Published: 19 July 2007 Abstract: In screening endophytic fungi from Costa Rica for bioactivity, fungal culture CR200, isolated from a buttonwood tree, was found to contain compounds that initiate DNA damage in a test strain of E...