2016年,FDA授予了PVSRIPO(靶向胶质细胞瘤CD155的非致病脊髓灰质炎病毒)疗法突破性资格认定,授予DNAtrix的DNX-2401溶瘤病毒产品(溶瘤腺病毒)治疗弥漫性桥脑内胶质瘤(DIPG)的快速通道名称。 2023年,亦诺微同时表达IL-12和PD-1蛋白的瘤内注射溶瘤病毒(oHSV)产品(MVR-T3011)临床II期试验单药治疗晚期黑色素瘤中位PFS...
Here in this multicenter phase 1/2 study we evaluated the combination of intratumoral delivery of oncolytic virus DNX-2401 followed by intravenous anti-PD-1 antibody pembrolizumab in recurrent glioblastoma, first in a dose-escalation and then in a dose-expansion phase, in 49 patients. The primary...
Here in this multicenter phase 1/2 study we evaluated the combination of intratumoral delivery of oncolytic virus DNX-2401 followed by intravenous anti-PD-1 antibody pembrolizumab in recurrent glioblastoma, first in a dose-escalation and then in a dose-expansion phase, in 49 patients. The primary...
et al. Oncolytic DNX-2401 virus for pediatric diffuse intrinsic pontine glioma. N. Engl. J. Med. 386, 2471–2481 (2022). Article PubMed Google Scholar Lang, F. F. et al. Phase I study of DNX-2401 (Delta-24-RGD) oncolytic adenovirus: replication and immunotherapeutic effects in ...
Gallego Perez-Larraya, J. et al. Oncolytic DNX-2401 virus for pediatric diffuse intrinsic pontine glioma.N. Engl. J. Med.386, 2471–2481 (2022). ArticlePubMedGoogle Scholar Lang, F. F. et al. Phase I study of DNX-2401 (Delta-24-RGD) oncolytic adenovirus: replication and immunotherapeuti...
DNX-2401DNAtrixΔ24-RGD insertion400Glioblastoma, ovarian cancer VCN-01VCN BiosciencesPH20 hyaluronidase insertion200Pancreatic cancer Colo-Ad1PsiOxus TherapeuticsChimeric Ad11/3 group B120Colon cancer, NSCLC, renal cancer, bladder cancer, and ovarian cancer ...
(NCT02636036, NCT02028117, NCT02028442, NCT03916510, NCT02053220), which was further engineered to generate the EnAd-EpCAM-BiTE and EnAd-FAP-BiTE vectors described in this review, DNX-2401 is among the clinically most advanced adenovirus-based oncolytics (NCT03896568, NCT03178032, NCT02798406, ...
Cancer Stem Cells (CSCs) are the main “seeds” for the initiation, growth, metastasis, and recurrence of tumors. According to many studies, several viral infections, including the human papillomaviruses, hepatitis B virus, Epstein–Barr virus, and hepat
57 An E1A/E1B-deleted virus (ONYX015) has been extensively tested and approved for treatment of head and neck cancer in China under the name H101.58 An integrin-binding retargeted adenovirus, Δ24RGD (DNX2401), has been examined in clinical trials42,59 in which the maximum tolerated dose...
As part of a phase 1, dose-escalation, biological-endpoint clinical study (NCT00805376) of DNX-2401 (Delta-24-RGD), a Rb-targeted, tumor-selective, replication-competent oncolytic adenovirus, conducted in 37 patients with recurrent malignant glioma, 12 patients received an intratumoral injection th...