基础胰岛素和GLP-1RA具有协同作用,可以进一步改善血糖控制,减少各成分的不良副作用,每周胰岛素和每周GLP-1RA的联合使用是一种很有前途的策略:GLP-1 RA与基础胰岛素联合使用时,无论是单独使用还是固定比例联合使用,均可改善HbA 1c疗效,并对体重和低血糖风险产生有利影响。 自2005年首个肠促胰岛素获批用于治疗T2 D以来...
The drug is a once-weekly subcutaneous injection used to improve glycemic control and is indicated as an adjunct to diet and exercise in the management of type 2 diabetes in adults.Gretchen L SchwenkerAdvanstar Communications Inc
Consider Ozempic® (semaglutide) injection, a once-weekly GLP-1 RA therapy for your patients with T2D who need additional glycemic control. Read Important Safety and Prescribing Information, including Boxed Warning.
SAN FRANCISCO — The once-weekly injectable glucagon-like peptide-1 (GLP-1) agonistdulaglutide(Trulicity,Lilly) for the treatment oftype 2 diabeteshas significantly reduced the risk of major adverse cardiovascular events (MACE) in theREWINDcardiovascular (CV) outcomes trial, primarily by reducing the...
Liraglutide is an acylated glucagon-like peptide-1 (GLP-1) analogue that binds to serum albumin in vivo and is approved for once-daily treatment of diabetes as well as obesity. The aim of the present studies was to design a once weekly GLP-1 analogue by increasing albumin affinity and secu...
2型糖尿病患者,有许多替代方案,包括口服抗糖尿病药物和注射剂,如胰高血糖素样肽-1受体激动剂(GLP-1RA)类药物---司美格鲁肽。美国糖尿病协会指出GLP-1 RA与基础胰岛素联合使用具有“有效的降血糖作用,更少的体重增加和低血糖”,并没有具体的建议。
Dulaglutide is a once-weekly GLP-1 receptor agonist for the treatment of type 2 diabetes. Steve Chaplin presents the clinical data relating to its efficacy and adverse events and Professor Stephen Bain discusses its place in therapy. S Chaplin,S Bain - 《Prescriber》 被引量: 2发表: 2015年 ...
机译:胰高血糖素样肽1(GLP-1)的骨干修饰,以改变GLP-1受体处的信号传导。 6.Clinical Effectiveness and Safety of Once-Weekly GLP-1 Receptor Agonist Dulaglutide as Add-On to Metformin or Metformin Plus Insulin Secretagogues in Obesity and Type 2 Diabetes[O].Maria Mirabelli,Eusebio Chiefari,Vera ...
1 (GLP-1) receptor agonist exenatide, slow release in the body to play long-term hypoglycemic effect by the microsphere technique, it can be administered once-weekly, 2 mg each time. The patient can be dosed at any time of the day, regardless of meal or not. Bydureon® has been ...
Exenatide is an "incretin mimetic" — a drug that mimics the action of naturally occurring hormones such as glucagon-like peptide-1 (GLP-1) that regulate blood glucose by stimulating insulin-dependent glucose secretion, inhibiting glucagon secretion, and slowing gastric emptying. Exenatide is commonly...