EZH1 is a homolog of EZH2 and forms an alternative for EZH2 in assembling the PRC2 complex. We investigated the effects of ONC201, ONC206 or ONC212 on EZH1/2 by treating DMG cells and a panel of other solid tumor cells including GBM, DMG, CRC, PDAC, SCLC, prostate cancer, HCC and...
We investigated the effects of ONC201, ONC206 or ONC212 on EZH1/2 by treating DMG cells and a panel of other solid tumor cells including GBM, DMG, CRC, PDAC, SCLC, prostate cancer, HCC and breast cancer cells with ONC201, ONC206 or ONC212. We observed that imipridones inhibit ...