Drug Discovery Today. 2022;27(2):436–55. Article CAS PubMed Google Scholar Pardridge WM. Drug transport in brain via the cerebrospinal fluid. Fluids Barriers CNS. 2011. https://doi.org/10.1186/2045-8118-8-7. Article PubMed PubMed Central Google Scholar Sariban E, Edwards B, Janus ...
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Today’s deal expands on a smaller collaboration the two companies forged in 2016. Two years ago, the companies began to explore the combination of NKTR-214 with Opdivo in five tumor types and seven potential indications. Currently a Phase I/II trial is ongoing wi...
While targeting of solid tumors still faces several hurdles [53,54,55], CAR T-cell targeting CD19 in leukemia and lymphoma has found its way into clinical application, due to high success rates achieved with the therapy [56,57]. However, the clinical use of CAR T-cells has also revealed...