This high sensitivity is generated in the retina; rods respond to single photons and there is a large amplification at the synapse with some bipolar cells (Ashmore & Falk 1976; 1980). The absorption of a photon within the receptive field of a ganglion cell of a dark-adapted retina has a ...
Most inherited retinal dystrophies display progressive photoreceptor cell degeneration leading to severe visual impairment. Optogenetic reactivation of retinal neurons mediated by ... 查看全部>> E Mace,R Caplette,O Marre,... 被引量: 0发表: 2014年 ...
Every 35 sec during the recording period, we provided a voltage ramp in darkness to test slope conductance followed by a strong 10 msec light flash to test the cell's ability to produce a light response (Fig. 2A). For cells that were patched with control solution in the pipette, ...
(Rod-ON-BCs). Whole-cell patch-clamp recordings showed that melatonin induced a sustained inward current from Rod-ON-BCs, through activation of the melatonin MT2 receptor, which was identified as one mediated by a cGMP-dependent cation channel. Consistent with this, melatonin was found, using ...
We found that the electroretinogram of Gβ5-/- mice lacks the b-wave component and that Gβ5-S and RGS11 colocalize with Goα at the tips of the ON-bipolar cell dendrites. Unexpectedly, we found a significant reduction in the number of synaptic triads in the outer plexiform layer (...
This review focuses on two of these molecules, Ca and cGMP, summarizing our current knowledge of how they modulate gain at the photoreceptor/ON bipolar cell synapse, as well as their proposed sites of action within the mGluR6 cascade. The implications of plasticity at this synapse for retinal ...
From their retina, we isolated hrGFP-positive cells by cell sorting, and analysed the gene-expression profile of these cells by using DNA microarray. Further analysis revealed that about half of the initially selected ON bipolar cell genes were expressed in the expected retinal layer. We confirmed...
Whole-cell recordings were obtained from On bipolar cells in slices of tiger salamander retina. Dialysis of cells with 1 [mu]M KN-62 or 10 [mu]M KN-93, two inhibitors of type II calmodulin-dependent protein kinase (CaMKII), depressed cGMP-dependent currents. This depression persisted when ...
Masu, M. et al. Specific deficit of the ON response in visual transmission by targeted disruption of the mGluR6 gene.Cell80, 757–765 (1995). ArticleCASGoogle Scholar Nagel, G. et al. Channelrhodopsin-2, a directly light-gated cation-selective membrane channel.Proc. Natl. Acad. Sci. USA...
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