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To further support these results, we treated mice with 100 mg/kg/day doxycycline, and this significantly decreased the total concentration of LPA species in plasma by ∼38% (Fig. 6F). Doxycycline also decreased plasma SIP concentration by ∼42% (Fig. 6F). DISCUSSION In the present study...
The glymphatic (glial-lymphatic) system is a fluid transport pathway playing an important role in clearing waste from the brain [1,2]. This pathway involves the flow of cerebrospinal fluid (CSF) transferring along the perivascular space into the brain interstitium, facilitated by the aquaporin-4 ...