EGFR敏感突变可从EGFR TKI治疗中取得获益,通过原发性或继发性耐药机制,肿瘤最终会发展为疾病进展,奥希替尼耐药机制包括“on-target”和“off-target”和转化表型等耐药机制,通过耐药机制的不断深入和细化,多种联合策略正涌现。 参考文献:Blaquier JB, Ortiz-Cuaran S, Ricciuti B, et al. Tackling osimertinib resi...
重要的是,“on-target”EGFR耐药突变和MET扩增患者可从amivantamab中获益更多,ORR为47%,中位缓解持续时间(DOR)为10.4个月,中位PFS为6.7个月。相反,除了MET,检测到旁路突变(包括RAS/RAF和mTOR 通路、细胞周期基因突变和ALK融合)患者对该联合模式...
正确顺序应该是on target-off tumor。一种药物或者其他小分子可以特异性结合肿瘤抗原，被用来治疗肿瘤。但是它可以与肿瘤抗原与结合以外，还可以与正常组织上的某种抗原结合。这种正常组织上的抗原可以与这种药物靶向结合，即为on target，但是又不在肿瘤上，即off tumor。药物靶向识别正常组织上的抗原，会损...
on-target off-tumor effect的意思 "On-target off-tumor effect"是一个生物学术语,通常用于描述在肿瘤靶向治疗过程中出现的副作用。 以car-t治疗为例,希望靶抗原只在肿瘤细胞上表达,这样就不会对正常组织细胞造成影响。然而,一些主要在肿瘤细胞上表达的抗原,其实在某些正常细胞也存在少量表达,因此car-t靶向治疗时...
identifying most off-targets with mutation rates superior to 0.1 %, while the number of false positives can be largely reduced with a cutoff on the off-target score. We also evaluate on-target efficiency prediction algorithms against available datasets. The correlation between the predictions and th...
On-target refers to exaggerated and adverse pharmacologic effects at the target of interest in the test system. Off-target refers to adverse effects as a result of modulation of other targets; these may be related biologically or totally unrelated to the target of interest. Both the risk ...
at locations in the genome other than the targeted site5,6. Suchoff-targetmutations can have serious consequences as they might disrupt the function or regulation of non-targeted genes. In addition, larger structural changes of the genome sequence, occurring at the intendedon-targetediting site, ...
Current popular sgRNA design tools only consider the sgRNA perfectly matched to the target site and provide the results without any on-target mismatch. We suppose taking on-target gRNA-DNA mismatches into consideration might provide better sgRNA with similar binding activity and reduced off-target ...
本篇文章我们介绍一下罗氏旗下Genentech利用三特异抗体解决靶向激活T细胞的On-target off tumor效应,其主要是通过抗体同时靶向肿瘤细胞表明不同的靶点,促进抗体对肿瘤细胞的定位,并特异性杀伤肿瘤。 1 同时靶向Ly6E和B7-H4 同时靶向肿瘤细胞表面两个不...
使用NAPI扩展TS接口时,常用属性和实现接口的基本用法 pthread创建的线程中如何读取rawfile ArkTS的SendableClass对象内存共享的原理和限制是什么 synchronized在java中可以修饰方法,从而简单地实现函数的同步调用。在系统ets开发中,如何简单实现该功能 ArkTS类的方法是否支持重载 如何将类Java语言的线程模型(内存共享...