OMP-54F28 is a fusion protein that combines the cysteine-rich domain of frizzled family receptor 8 (Fzd8) with the immunoglobulin Fc domain that competes with the native Fzd8 receptor for its ligands and antagonizes Wnt signaling. Preclinical models with OMP-54F28 have shown reduced tumor ...
Abstract 1907: Wnt pathway antagonist OMP-54F28 (FZD8-Fc) inhibits tumor growth and reduces tumor-initiating cell frequency in patient-derived hepatocellular carcinoma and ovarian cancer xenograft models The anti-tumor effect was associated with a decrease in cell proliferation, induction of cell diff...
Targeting the Wnt pathway in human cancers: Therapeutic targeting with a focus on OMP-54F28 喜欢 0 阅读量: 15 作者:Jimeno,Antonio,Le,Phuong,N.,McDermott,Jessica,D.摘要: The Wnt signaling pathways are a group of signal t 关键词:OMP-54F28 Wnt inhibitor Frizzled family receptor 8 ...