Hypertension is a major modifiable risk factor that affects the global health burden. Despite the availability of multiple antihypertensive drugs, blood pressure is often not optimally controlled. The prevalence of true resistant hypertension in treated
Genetic mechanisms of blood pressure regulation remain poorly defined. Here, the authors perform a kidney multi-omics study to identify 399 kidney effector genes, 11 miRNAs and 97 proteins for blood pressure and hypertension.Xu, XiaoguangKhunsriraksakul, Chachrit...
High-throughput techniques allow us to measure a wide-range of phospholipids which can provide insight into the mechanisms of hypertension. We aimed to conduct an in-depth multi-omics study of various phospholipids with systolic blood pressure (SBP) and diastolic blood pressure (DBP). The associati...
Broadening the scope of epigenomic data to include diverse populations could enhance the interpretation of GWAS loci, offering vital insights into the regulatory mechanisms affecting diseases that disproportionately impact non-European populations, like prostate cancer, hypertension, and chronic kidney disease...
Information on classical cardiovascular risk factors and potential confounders (age, sex, body mass index, systolic and diastolic blood pressure, hypertension, hypertension medication, diabetes, diabetes medication, history of myocardial infarction, smoking) was collected by questionnaire and from medical ...
In addition to demographic information, medical histories of vascular risk factors such as hypertension, hyperlipidemia, diabetes, smoking and cardiovascular disease were collected and classified as absent or present. Hypertension was defined as systolic blood pressure ≥ 140 mmHg and /or diastolic ...
It is characterized by the new onset of hypertension, proteinuria and other signs such as vascular endothelial damage20. The life-threatening condition known as severe PE (sPE) is diagnosed based on higher blood pressure criteria (systolic ≥ 160 mm Hg or diastolic ≤ 100 mm...
A healthy heart comprises various cell types, including cardiomyocytes, endothelial cells, fibroblasts, immune cells, and among others, which work together to maintain optimal cardiac function. These cells engage in complex communication networks, known
Hypertension, characterised by a constant high blood pressure, is the primary risk factor for multiple cardiovascular events and a major cause of death in adults. Excitingly, innovations in high-throughput technologies have enabled the global exploration of the whole genome (genomics), revealing dysregu...
In-depth multi-omics profiling was performed, including whole-genome sequencing (203 samples) and transcriptome sequencing (RNA-seq and miRNA-seq of 178 samples) of whole blood. Concurrently, liquid chromatography-mass spectrometry (LC-MS) was conducted to capture the proteomic, metabolomic, and lip...