Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet. 2020;395:507–13. Article CAS PubMed PubMed Central Google Scholar Chan JF, Yuan S, Kok KH, To KK, Chu H, Yang J, et al. A familial cluster of ...
In SARS-CoV-2, the polyprotein pp1a is proteolytically cleaved into 11 functional NSPs, whereas pp1ab is cleaved into 15 NSPs (Fig.1c). Each NSP plays specific or multifaceted roles in the viral life cycle. Nsp1 interacts with the host ribosome to inhibit the synthesis of host proteins....
In Germany, in mid-October 2022, over 172 thousand new cases have been recorded daily [87]. RNA viruses exhibit a high tendency to mutate [88]. In 2019, the wild type SARS-CoV-2 has been identified, later labeled the Hu-1 variant. The Hu-1 variant has mutated several dozen times, ...
As of 29 June 2022, Thailand has reported a cumulative total of 4,520,220 confirmed cases with 30,634 deaths [14]. Unlike many countries in the world, Thailand has a well-developed public health system with free medical health centers in every part of the country. The health centers are...
In addition, there are five lineages of the Omicron variant, i.e., BA.1 to BA.5. Although BA.1 was the original predominant strain, BA.2 is rapidly overtaking it in many countries. At most, there are a few hundred cases of BA.3, which has very limited transmissibility. Pango ...
SARS-CoV-2 is the causal agent of the new pandemic disease COVID-19. The spectrum of clinical manifestations following SARS-CoV-2 infection spans from very mild to severe symptoms [1], while asymptomatic cases of this disease further its infectious spread [2,3]. When SARS-CoV-2 infection ...
It was the first real-life data to examine the effect boosters against Omicron, which now accounts for more than 99% of coronavirus cases in the United States. The studies raised the question of whether people with just two vaccine doses should still be considered fully vaccinated. “I thin...