Omeprazole is usually well-tolerated in dogs and cats. Omeprazole is usually better than H2 blockers, such as famotidine, for longer-term use. What Follow-up Is Required With Omeprazole? You and your veterinarian should monitor your pet for improvement of their condition, as well as for side ...
Omeprazole may also have certain side effects for dogs, especially when taken in the wrong amount without the prescription of a professional. Potential side effects of omeprazole include: Diarrhea Gas Decreased appetite Nausea Flatulence Abdominal pain (rare) Risks Associated With Long-Term Use One mu...
Toxicological studies in rats have demonstrated that supramaximal doses of omeprazole administered for long periods cause gastric enterochromaffin-like cell hyperplasia and carcinoids, a few with proliferations into the submucosa. It has been suggested that hypergastrinaemia, induced by the profound inhib...
Long-term use in humans33 and dogs11 is associated with gastric polyps and parietal cell hyperplasia, respectively, but the effect of long-term use in cats is currently unknown. Read full chapterView PDFExplore book Pharmacogenomics and drug metabolism Vishakha Tambe, ... Rakesh Kumar Tekade, ...
We do not want to obliterate the stomach's ability to produce acid long term. For this reason omeprazole is best used for periods of 4 weeks or less.SIDE EFFECTSIncreases in liver enzymes may be induced by the use of omeprazole. This is not harmful but should be recognized as an ...
The prostaglandin analog misoprostol exhibited no evidence of carcinogenicity in rats Dodd et al (1987) and mice Port et al (1987) given relatively low oral doses for up to 24 months, although larger doses have been reported to cause gastric mucosa hyperplasia in dogs and reduced the number ...
long-term treatmentomeprazoleTwo series of experiments have been performed in gastric fistula dogs to test the antisecretory effect of two different oral dosage forms of omeprazole: 2 mol ± kg1 ± day1 as a methylcellulose suspension for 8 weeks and 0.5 mol ± kg1 ± day1 in enteric-...
Control of the complex mechanism of gastric acid secretion has thus long been a goal for the management of such diseases. This article describes the key discoveries and challenges in the discovery and development of omeprazole, the first in a class of antisecretory drugs that act by inhibiting ...
Four years later, the patient was still free from edema. Inflammatory involvement of the gastric mucosa probably caused protein losing in this patient. Recognition of this exsudative gastropathy is important because long term remission is obtained with omeprazole. 展开 被引量: 1 年份: 2000 ...
Long-termOmeprazoleParietal cellsTen beagle dogs were given omeprazole orally at a dose of 0.17 mg/kg (0.5 μmol/kg) daily for 7 years. Six dogs served as controls. Regularly evaluated criteria were clinical signs, body weight, food consumption, rectal temperature, electrocardiography, hematology,...