Bone formationBone resorptionHydroxyprolineOmeprazoleOsteocalcin OsteoporosisOvariectomized ratBACKGROUND: Several epidemiologic studies have suggested the association between therapy with proton pump inhibitors (PPIs) and bone fractures.HASANIN, A. H.
Bone Fracture:Long-term and multiple daily dose PPI therapy may be associated with an increased risk for osteoporosis-related fractures of the hip, wrist or spine. ( 5.4) Severe Cutaneous Adverse Reactions:Discontinue at the first signs or symptoms of severe cutaneous adverse reactions or other ...
Long-term use of omeprazole, particularly beyond the recommended durations, may increase the risk of certain health issues, such as nutrient deficiencies (e.g., magnesium, calcium, and vitamin B12), bone fractures, and gastrointestinal infections. Omeprazole can also alter the acidity of the ...
Long-term use of omeprazole, especially at high doses and for extended periods, may be associated with a slightly increased risk of bone fractures. Possible interactions may occur with other pharmaceutical products. Consult with a doctor or pharmacist about any medications and supplements you are ta...
Long-term use may be associated with risks like vitamin deficiencies and bone fractures, highlighting the importance of medical supervision. 5 Can I use omeprazole or esomeprazole for immediate heartburn relief? These medications are not intended for immediate relief but rather for long-term management...
Clostridium difficile-Associated Diarrhea: PPI therapy may be associated with increased risk; use lowest dose and shortest duration of treatment. (5.9) Bone Fracture: Long-term and multiple daily dose PPI therapy may be associated with an increased risk for osteoporosis-related fractures of the hip...
Bone loss and fractures.Omeprazole may cause bone loss and increase your risk for fractures. The risk is higher in older adults and people taking omeprazole for a long time or taking a high dose. Severe Allergic Reactions.Omeprazole may causeallergic reactions, which can be serious. Stop using...
Common side effects include nausea, vomiting, headaches, and increased intestinal gas. Serious side effects may include Clostridium difficile colitis, an increased risk of pneumonia, an increased risk of bone fractures, and the potential of masking stomach cancer. It is unclear if it is safe ...
Proton pump inhibitors may increase the risk ofClostridium difficileinfection. High doses and long-term use (1 year or longer) may increase the risk ofosteoporosis-relatedfracturesof the hip, wrist, or spine. Prolonged use also reduces absorption of vitamin B12 (cyanocobalamin). ...
Acute Tubulointerstitial Nephritis [see WARNINGS AND PRECAUTIONS] Clostridium difficile-Associated Diarrhea [see WARNINGS AND PRECAUTIONS] Bone Fracture [see WARNINGS AND PRECAUTIONS] Severe Cutaneous Adverse Reactions [see WARNINGS AND PRECAUTIONS] Cutaneous and Systemic Lupus Erythematosus [see WARNINGS AND ...