Apoptosis, deactivation, and reprogramming of myofibroblasts are important processes in the resolution of fibrosis. Here we report that omentin-1 reverses established lung fibrosis by promoting mechanically activated myofibroblasts dedifferentiation into lipofibroblasts. Omentin-1 promotes myofibroblasts lipogenic ...
Acute lung injuryOmentin-1InflammationOxidative stressNF-κB pathwayAcute lung injury (ALI) is characterized by inflammatory cell infiltration, macrophage activation, and excessive pro-inflammatory cytokine production. Bleomycin (BLM) is widely used to induce acute lung injury (ALI) and fibrosis in ...
Nowadays, it is known that, in addition to its relation to cancer, NOV/CCN3 plays an important role in organogenesis, inflammation or fibrosis [164,165]. All these functions are mediated by its interaction with integrins and by the Notch pathway, which regulates cell-fate during development ...