产品标签: Oligomycin A寡霉素A线粒体F1Fo ATP合酶FCCP细胞凋亡诱导剂CAS:579-13-5在线询价收藏产品 进入展商展台 联系方式:杨超18616957973 联系我们时请说明是 环保在线 上看到的信息,谢谢!索取相关资料公司介绍主营产品 上海懋康生物科技有限公司是一家致力于生命科学和生物技术领域的高科技企业。公司由在国内...
Mitochondria ATP-production during no incubation and after oligomycin, FCCP or CAT in control and diabetic animals without scrambled or UCP-2 siRNA.Malou, FriederichPerssonShakil, AslamLina, NordquistWilliam, J. WelchChristopher, S. W...
Rapid kinetics analysis shows that carbonyl-cyanide- p -trifluoromethoxyphenyl-hydrazone (FCCP) does not exert any direct effect on redox-linked active proton transport. The uncoupling action of FCCP on oxidative phosphorylation and energy-linked transhydrogenase is shown to be quantitatively accounted ...
We replaced CCCP by FCCP, another potent protonophore and similar results were observed. Lower maximal OCR and SRC values were obtained with the weaker protonophore 2,4-dinitrophenol, and these parameters were not affected by the presence of oligomycin. In permeabilized cells or isolated brain ...
Effect of oxidative phosphorylation uncoupler FCCP and F1F0-ATPase inhibitor oligomycin on the electromechanical activity of human myocardium. Adv Med Sci 2007;52:89-93.Zablockaite D, Gendviliene V, Martisiene I, Jurevicius J. Effect of oxidative phosphorylation uncoupler FCCP and F1F0-ATPase ...
While certain natural products act as mitochondrial uncouplers, most of the protonophores used as pharmacological probes are not natural products but are low-molecular-weight synthetic compounds (e.g., carbonyl cyanide p-trifluoromethoxyphenylhydrazone (FCCP)). 2.20.2.5.4 ATPase inhibitors The ...
2B, the stimulation of OCR in the presence of FCCP is also shown. Interestingly, FCCP displays a bell-shaped concentration response in these cells. Again, selection of the proper concentration is crucial to effectively obtain the maximal OCR in response to FCCP. For each cell line used, we ...
Upon addition of FCCP, the medium sharply acidified, owing to the hydrolysis of ATP by the ATP synthase to generate a membrane potential. The interpretation is reinforced by addition of oligomycin, inhibiting activity of the enzyme and causing the medium pH to return to the initial value. ...
Oligomycin, rotenone and FCCP are toxic and should be handled with care. • DMSO has the potential to carry toxic materials or materials of unknown toxicity into the body. DMSO is readily absorbed through skin. DMSO may be irritating to the mucous membranes and upper respiratory tract. View ...
This latter effect appears to have been mediated by a partial reassociation of the inhibitor protein with the enzyme, and it was accentuated (when FCCP was added at the end of the incubations) or mimicked (when FCCP was absent) by lowering the pH of the re-energization medium. A close ...