Previously unrecognized as a unique cell type, oligodendrocyte precursor cells (OPCs) have now been identified via their expression of a specific marker antigen, NG2. In the following discussion, the characteristics of OPCs are elucidated within the context of research on how new myelin is pro-...
we identified bidirectional crosstalk between the neural and the vascular compartment of the developing CNS required for oligodendrocyte precursor cell specification. Mechanistically, we show that neural progenitor cells (NPCs) express angiopoietin-1 (Ang1) and that this expression is regulated by Sonic ...
Stem Cell Astrocyte Progenitor Cell Myelination Precursor Mouse Remyelinization View all Topics Featured Authors Álvarez-Buylla, Arturo University of California, San Francisco, San Francisco, United States Citations 54,745 h-index 112 Publications 64 Schwab, Martin Ernst Universität Zürich, Zurich...
domain expands or shrinks after it is first established. On the right are shown the cell fates of progenitors in the indicated domains (the origins of astrocytes are still tentative). FP, floor plate; INs, interneurons; MNs, motor neurons; OPCs, oligodendrocyte precursor cells; RP, roof ...
c-Jun N-terminal kinase 1 (JNK1) modulates oligodendrocyte progenitor cell architecture, proliferation and myelination Introduction Oligodendrocyte precursor cells (OPCs; also known as oligodendrocyte progenitor cells, polydendrocytes, or O-2A cells) are glial cells that possess the potential to give ...
They differentiate from oligodendrocyte precursor cells through several intermediate states that can be followed by characteristic morphological changes and the expression of marker molecules. However, most oligodendrocyte lineage markers demarcate either the precursor or the differentiated oligodendrocyte in ...
CNTF promotes the survival and differentiation of adult spinal cord-derived oligodendrocyte precursor cells in vitro but fails to promote remyelination in ... Delivery of factors capable of promoting oligodendrocyte precursor cell (OPC) survival and differentiation in vivo is an important therapeutic stra...
Stage 1: Neural precursor production. In the beginning, hECS colonies were mechanically cut into small clusters and directly transferred into neural inductor medium as described earlier (Nat et al., 2007). Differentiating neural cell aggregates were cultured for 4 or 8 weeks in N2 medium ...
Determination of Neuroepithelial Cell Fate: Induction of the Oligodendrocyte Lineage by Ventral Midline Cells and Sonic Hedgehog Near the floor plate of the embryonic neural tube there is a group of neuroepithelial precursor cells that are specialized for production of the oligodendr... NP Pringle,...
1. A cell culture comprising a cell culture medium comprising a ceramide compound in combination with a S1P receptor agonist, wherein said cell culture is enriched with oligodendrocyte precursor cells (ODPCs) capable of further differentiating into oligodendrocytes in vivo without forming teratomas, whe...