Given that manual annotation of the olfactory bulbs in MRI to determine their volume is tedious, we propose a method for their automatic segmentation. To mitigate the class imbalance caused by the small volume of the olfactory bulbs, we first localize the center of each olfactory bulb in a ...
., 2003; Maresh et al., 2008; Smith, 1942; Zapiec et al., 2017), and a recent study found normal olfactory abilities in humans with no observable olfactory bulbs on MRI scans (Weiss et al., 2020), suggesting wide individual variation in the overall shape of the human olfactory bulb....
This cohort study evaluates the association of COVID-19 infection with olfactory bulb by performing an ultrastructural and histopathological analysis of
Thomann PA, Dos Santos V, Seidl U, Toro P, Essig M, Schroder J (2009) MRI-derived atrophy of the olfactory bulb and tract in mild cognitive impairment and Alzheimer’s disease. J Alzheimers Dis 17:213–221 PubMed Google Scholar Thompson MD, Knee K, Golden CJ (1998) Olfaction in pe...
In postmortem biopsies, COVID-19 patients showed elevated IFN and inflammatory gene expression in the olfactory bulb [44]. Consistent with this, patients with olfactory dysfunction have detectably larger olfactory bulbs measured by MRI [123, 124]. This prolonged inflammation is likely driven by ...
Olfactory dysfunction is a prevalent non-motor symptom of Parkinson’s disease (PD). This dysfunction is a result of neurodegeneration within the olfactory bulb (OB), the first processing area of the central olfactory system, and commonly precedes the ch
terminating directly in the olfactory bulb of the brain [1]. As a result, olfaction is a sensitive and efficient process for communicating information about the external environment. However, precisely because the OM simultaneously straddles the airway and the brain, microbes can subvert this biology...
Khan M, Yoo S-J, Clijsters M, Backaert W, Vanstapel A, Speleman K et al (2021) Visualizing in deceased COVID-19 patients how SARS-CoV-2 attacks the respiratory and olfactory mucosae but spares the olfactory bulb. Cell 184:5932-5949.e15 Article CAS PubMed PubMed Central Google Schola...
MRIAquaporin 4Olfactory bulbFew data were available for the understanding of olfactory function in neuromyelitis optica spectrum disorders (NMOSDs). The aims of our study were to investigate the incidence of olfactory dysfunction and characterize olfactory structures, using MRI, in patients with NMOSDs...
Anosmia in COVID-19 associated with in- jury to the olfactory bulbs evident on MRI. Ajnr Am J Neuroradiol. 2020;41:1703–6. 50. Laurendon T, Radulesco T, Mugnier J, Gérault M, Chag- naud C, El Ahmadi A-A, et al. Bilateral transient olfactory bulb edema during COVID-19-related...