Bax lethality (20), allowing the identification of BI-1, a highly conserved apoptosis inhibitor (21), enzymes involved in the ROS detoxification such as BI-GST (22) and ascorbate peroxidase (23), and Ku70, an e
As it concerns the molecular mechanisms of action, estrogenic GPER signaling engages several rapid transduction cascades such as MAPKs and PI3K/AKT, which in turn activate the intracellular transcriptional machinery, leading to stimulatory effects in cancer cells, as well as in components of the ...