Olanzapine was not associated with significant sedation, weight gain, or induction of hyperglycemia. Previously conducted studies have shown the efficacy and safety of olanzapine for controlling chemotherapy-associated nausea and vomiting [46], and in this setting, it has been used in combination ...
There are different theories as to why this occurs, but the most recently studied theory is that these drugs which cause weight gain do so because of an antagonist effect at the 5HT2C receptor. In this work, we studied the effects of olanzapine, clozapine, and risperidone on feeding behav...
The deleterious effects of olanzapine on serum lipids can be independent of the body mass index or, in addition, to weight- related effects.17 Albaugh et al.18 recently proposed an interesting mechanism to explain why olanzapine might cause metabolic side effects leading to obesity and diabetes ...
Some cases reported previous weight gain, which may be a contributing factor, and it is suggested that patients with diabetes and people with diabetes risk factors should be properly monitored. When the nitrogenation was stopped suddenly, the following acute symptoms such as sw...
Here, lurasidone (both as mono- and combined therapy) was superior compared to the olanzapine/fluoxetine combination (which led to significant weight gain and diarrhea) and quetiapine (which led to significant sleepiness and dry mouth). Overall, there is convincing evidence that some seco...
Olanzapine is one of the most commonly prescribed second-generation antipsychotic drugs. Notoriously known for metabolic side-effects such as weight gain and diabetes, olanzapine has also been demonstrated to cause neurodegeneration. However, there is limited mechanistic knowledge surrounding this area. Her...
In the long-term clinical trial (at least 24 weeks), the degree of weight gain and the proportion of clinically significant weight gain in the olanzapine treatment group were higher than those in the short-term clinical trial and adult group. About half of the adolescent patients gaine...
Antipsychotics (APs) are linked to diabetes, even without weight gain. Whether anti-diabetic drugs are efficacious in reversing the direct effects of APs on glucose pathways is largely undetermined. We tested two metformin (Met) doses to prevent impairme
(olanzapine): somnolence, dry mouth, dizziness, asthenia, constipation, dyspepsia, increased appetite, and tremor Bipolar I Disorder, Manic or Mixed Episodes, adjunct to lithium or valproate (olanzapine): dry mouth, weight gain, increased appetite, dizziness, back pain, constipation, speech ...
which is believed to attenuate EPS. However, these agents are largely ineffective against negative symptoms and cognitive deficits, with the exception of clozapine in regards to negative symptoms. Many atypicals exhibit their own side effects that may include metabolic syndrome (weight gain and diabete...