Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of olanzapine in the elderly. However, elderly patients are more likely to have dementia or age-related liver, kidney, or heart problems, which may require caution or an adjustment...
Contact a Certified Poison Control Center for the most up to date information on the management of overdosage (1-800-222-1222). For specific information about overdosage with lithium or valproate, refer to the Overdosage section of the prescribing information for these products. For specific info...
Study participants were treated with olanzapine and followed up for up to 12 months. Outcomes were assessed at baseline, at 8 weeks, 16 weeks, 6 months and 12 months after starting olanzapine. The study adhered to CONSORT guidelines. The cut-off point of 2 kg weight gain within one month ...
Oral olanzapine should be administered on a once-a-day schedule without regard to meals with a recommended starting dose of 2.5 or5 mg, with a target dose of 10 mg/day. Efficacy in adolescents with schizophrenia was demonstrated based on a flexible dose range of 2.5 to 20 mg/day inclinica...
Bodyweight gain in the range of approximately 2 to 3.5kg was associated with olanzapine treatment in 6-week clinical trials and was significantly higher than that seen with haloperidol or risperidone. In extension phases (for up to 3 years) of the acute phase trials, bodyweight gain appeared ...
To date, such reports are from uncontrolled clinical experience and therefore cannot clarify whether the atypical antipsychotics caused such manic-like states or simply failed to prevent them. Presumably, bipolar patients would be at increased risk for this putative adverse event. Therefore, we ...
If foam forms, let vial stand to allow foam to dissipate. If the product is not used right away,it should be shaken vigorously to re-suspend. Reconstituted ZYPREXA RELPREVV remains stable at room temperature for up to 24 hours in the vial. ...
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Olanzapine and clozapine demonstrated pronounced dose-dependent effects on serum corticosterone 60 min following i.p. injection in male Sprague–Dawley rats, increasing corticosterone up to 10- and 8.5-fold, respectively (Table 1). Olanzapine 5.0 mg/kg (n=21) and 10.0 mg/kg (n=31) ...
This patient was discharged with 10 mg/night of olanzapine, 800 mg/day of amisulpride and 2 mg/night of lorazepam, while we planned to gradually discontinue olanzapine for outpatient treatment. At the follow-up after 6 months, the patient reported taking the medication regularly, and the arm ...