Oral olanzapine should be administered on a once-a-day schedule without regard to meals, generally beginning with 5 to 10 mg initially,with a target dose of 10 mg/day within several days. Further dosage adjustments, if indicated, should generally occur at intervals of not less than 1 week,s...
defined in terms of increases in BPRS positive symptoms or hospitalization, was planned for 12 months, however, criteria were met for stopping the trial early due to an excess of placebo relapses compared to olanzapine relapses, and olanzapine was superior to placebo on time to relapse, the pr...
A woman was taking olanzapine 5 mg orally 3 times daily, amounting to 270 mcg/kg daily. After 11 days on olanzapine, a milk sample was taken just before nursing (time after dose not reported). The concentration of olanzapine was 12 ng per gram of breastmilk. The authors estimated that ...
(cn 1-may-2020)•b.the retention time of the major peak of the sample solution corresponds to that of the standard solution, as obtained in the assay. assay•procedure buffer:dissolve 6.9 g of monobasic sodium phosphate in 1 l of water. adjust with phosphoric acid to a ph of 2.5, ...
with reference to olanzapine (retention time =about 13min):impurity B =about 0.3;impurity D =about 0.9;impurity C =about 1.2.System suitability :reference solution (b):—resolution :minimum 1.5between the peaks due to impurity D and olanzapine.Limits :—correction factor :for the ...
Free Asp enantiomers were resolved by HPLC as single defined peaks with a retention time of 4.8 ± 0.1 min for D-Asp and 5.5 ± 0.1 min for L-Asp, while the peak corresponding to free L-Glu was detected at 8.0 ± 0.2 min (Fig. 1b). The ...
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considered treatment emergent if it occurred for the first time or worsened while receiving therapy following baseline evaluation. Reactions listed elsewhere in labeling may not be repeated below. The entire label should be read to gain a complete understanding of the safety profile of ZYPREXA ...
comprising olanzapine, wherein the dose is administered by an intranasal delivery device that provides, following intranasal administration, (a) a mean peak plasma olanzapine concentration (Cmax) of at least 30 ng/mL, with (b) a mean time to Cmax (Tmax) of olanzapine of less than 0.5 hours...
The patient did not inform her doctor in time, as she was concerned that she would not be discharged. She had similar discomfort in the past while taking 20 mg/day of olanzapine and needed to take 2 mg/night of clonazepam to help with sleep. Based on these observations, we considered ...