Laboratory tests, including routine blood test, hepatic function test, blood glucose monitoring, lipid panel screen, and electrocardiograph, were conducted at the beginning and the end of the treatment. Statistical analyses Data were on an intent-to-treat basis, and included all patients who met ...
3E–G). Taken together, these results suggested that intact PCSK9 expression was required for olanzapine-induced steatosis, and the beneficial effect of metformin on olanzapine-induced lipid accumulation was dependent on PCSK9. Recent studies have suggested a positive correlation between serum PCSK9 ...
The NCC drug library contains small molecule compounds that have a history of use in human clinical trials. We performed an exploratory drug screen of 595 compounds from the NCC library, testing each compound at a concentration of 2 μM, and we identified 134 hits (Additional file7). We the...
Specifically, we performed correlation between the changes in the brain activity in these ROIs and various psycho-physiological measures (for example, TFEQ or Positive and Negative Symptoms Scale scores, concentration of metabolites, and so on). In addition, we estimated the values of the BOLD ...
Use an alternative analytical technique (e.g., chromatographic methods) to confirm positive opioid urine drug screen results. Most Common Adverse Reactions observed in clinical trials were: Schizophrenia (LYBALVI): weight increased, somnolence, dry mouth, and headache Bipolar I Disorder, Manic or ...
in our drug screen, we found that imipramine and olanzapine strongly inhibited the apoE4-catalyzed fibrillization of Aβ, whereas none of the other antidepressants or antipsychotics in the NCC library had any such activity. In line with our identified mechanism of action, these apoE4 inhibitors al...
Laboratory tests, including routine blood test, hepatic function test, blood glucose monitoring, lipid panel screen, and electrocardiograph, were conducted at the beginning and the end of the treatment. Statistical analyses Data were on an intent-to-treat basis, and included all patients who met ...
(Day 1, peak concentration of olanzapine; Day 2_1, peak concentration of domperidone) as well as the non-peak effects (Day 2_2 and Day 3). It is also possible that the peak effect of olanzapine on QT interval occurs initially, coinciding with the autonomic effects of the drug, although...
treatment course. This study provides further evidence to support clinical research to test the effectiveness of co-treatment with olanzapine and SEP-363856 for controlling the positive symptoms, cognitive impairment, and the weight gain side effect in schizophrenia with long term antipsychotic treatment....