To assess the bioequivalence of two 5-mg olanzapine orally disintegrating tablet (ODT) products, 2 randomized, open-label, single-dose, 2-way crossover studies were carried out under fasting or fed conditions. Blood samples were collected at scheduled times according to the study protocol. ...
In the case of an orally disintegrating tablet (ODT), disintegration time is one of the essential attributes for ensuring that the ODT disintegrates within the recommended United States Pharmacopeia (USP) time of 30 s or the European Pharmacopoeia (Ph. Eur.) time of 3 min [42,47,48]...