Maximum dose: 20 mg/dayAdjunctive Treatment with Lithium or Valproate:Initial dose: 10 mg orally once a day Maintenance dose: 5 to 20 mg orally once a day Maximum dose: 20 mg/dayTreatment of Depressive Episodes Associated with Bipolar I Disorder (In Combination with Fluoxetine):Initial...
reaching maximum plasma concentrations approximately 4 and 6 hours after a fixed oral dose of olanzapine/ fluoxetine 12 mg/50 mg. The agents are extensively metabolized in the liver; olanzapine
Olanzapine was not teratogenic when administered orally to pregnant rats and rabbits at doses that are 9- and 30-times the daily oral maximum recommended human dose (MRHD), based on mg/m2 body surface area; some fetal toxicities were observed at these doses (see Data). The estimated back...
Risk of clinically important orthostatic hypotension associated with use of maximum recommended IM dosages of immediate-release olanzapine injection (i.e., three 10-mg IM doses given 2–4 hours apart). If drowsiness or dizziness occurs, patients should remain recumbent until examination indicates ...
Mean maximum daily olanzapine dose was 26 mg. For the group, mean improvement at twelve weeks was 11% in total PANSS score, 13% in positive subscale and 15% in negative subscale. Using > 25% improvement in total PANSS score as criterion, none of the patients could be categorized as ...
dose, subsequent doses up to 10 mg may be given. However, the efficacy of repeated doses of intramuscular olanzapine for injection inagitated patients has not been systematically evaluated in controlled clinical trials. Also, the safety of total daily doses greater than 30 mg, or 10 mg...
Olanzapine was not teratogenic when administered orally to pregnant rats and rabbits at doses that are 9- and 30-times the daily oral maximum recommended human dose (MRHD), based on mg/m 2body surface area; some fetal toxicities were observed at these doses (see Data). The estimated back...
Both olanzapine and fluoxetine are well absorbed following oral administration, reaching maximum plasma concentrations approximately 4 and 6 hours after a fixed oral dose of olanzapine/ fluoxetine 12 mg/50 mg. The agents are extensively metabolized in the liver; olanzapine predominantly via cytochrome ...
A slow titration schedule was followed, comprising weekly increments of 1.25 or 2.5 mg/day for adolescents and 2.5 mg/day for adults, up to a maximum of 10 mg/day for both. Feasibility parameters The primary feasibility parameters to assess the feasibility of a future definitive RCT included ...
The usual oral dose of olanzapine for treating schizophreniais 10-20 mg once daily. Therapy is initiated with 5-10 mg/day, and the dose may be increased by 5 mg a day at weekly intervals. The maximum dose is 20 mg daily. The recommended dose of extended release injection is 150-405 ...