• Lorazepam (IM):Increased somnolence with IM olanzapine. ( 7.2) • Other Concomitant Drug Therapy:When using olanzapine in combination with lithium or valproate, refer to the Drug Interactions sections of the package insert for those products. ( 7.2) Use In Specific Populations • Preg...
Oral dosage 10 mg per day: Give 210 mg IM every 2 weeks or 405 mg IM every 4 weeks for 1st 8 weeks, then 150 mg every 2 weeks or 300 mg every 4 weeks Oral dosage 15 mg per day: Give 300 mg IM every 2 weeks for 1st 8 weeks, then 210 mg every 2 weeks or 405 mg every ...
Olanzapine IM is a short-acting formulation that may be given to adults with schizophrenia or bipolar I mania if they have become agitated. The usual dosage of olanzapine IM is 10 mg as a single dose. Smaller dosages (5 mg or 7.5 mg) can be given if these are more appropriate. ...
Oral ZYPREXA and fluoxetine in combination is indicated for the treatment of depressive episodes associated with bipolar I disorder, based on clinicalstudies. When using ZYPREXA and fluoxetine in combination, refer to the Clinical Studies section of the package insert for Symbyax. ZYPREXA monotherapy is...
Lorazepam (IM) Co-administration of lorazepam does not significantly affect the pharmacokinetics of olanzapine, un conjugated lorazepam, or total lorazepam. However, this co-administration of lorazepam with olanzapine potentiated the somnolence observed with either drug alone. ...
(olanzapine incidence at least twice that for placebo)during the placebo-controlled premarketing studies. The incidence of somnolence during the 24 hour IM treatment period in clinical trials in agitatedpatients with schizophrenia or bipolar I mania was 6% for intramuscular olanzapine for injection and...