Half-lifeOral administration: 21–54 hours.IM administration of short-acting olanzapine injection: Half-life similar to that observed with oral administration.IM administration of extended-release olanzapine pamoate injection: Approximately 30 days. Exposure to olanzapine may persist for months after a ...
Taking olanzapine with other drugs that make you sleepy or slow your breathing can cause dangerous or life-threatening side effects. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures. ...
Efficacy was demonstrated in 3 short-term (24 hours of IM treatment) placebo-controlled trials in agitated adult inpatients with: schizophrenia or bipolar Idisorder (manic or mixed episodes) [seeClinical Studies] . “Psychomotor agitation” is defined in DSM-IV as “excessive motor activity associa...
Olanzapine is well absorbed after oral administration and is metabolized mainly by CYP1A2 to inactive metabolites, with a variable half-life of approximately 20 to 50 hours.10. Computational chemical data Molecular Weight: 312.4325g/mol Molecular Formula: C17H20N4S Compound Is Canonicalized: True ...
neuropharmacological profile, in that it is a more potent antagonist at dopamine D2 and, especially, serotonin 5-HT2A receptors. Olanzapine is well absorbed after oral administration and is metabolized mainly by CYP1A2 to inactive metabolites, with a variable half-life of approximately 20 to 50...
Lorazepam (IM) Co-administration of lorazepam does not significantly affect the pharmacokinetics of olanzapine, un conjugated lorazepam, or total lorazepam. However, this co-administration of lorazepam with olanzapine potentiated the somnolence observed with either drug alone. ...
This study has several pragmatic aspects of clinical relevance. First, it mimics real-life clinical practice, such as when an antipsychotic combined with an antidepressant for TRD treatment is being considered for discontinuation. When this occurs, it is likely that the same antidepressant will be ...
Plasma concentrations, half-life, and clearance of olanzapine may vary between individuals on the basis of smoking status, gender, and age. Olanzapine is extensively distributed throughout the body, with a volume of distribution of approximately 1000 L. It is 93% bound to plasma proteins over ...
Efficacy was demonstrated in 3 short-term (24 hours of IM treatment) placebo-controlled trials in agitated adult inpatients with: schizophrenia or bipolar Idisorder (manic or mixed episodes) [seeClinical Studies] . “Psychomotor agitation” is defined in DSM-IV as “excessive motor activity associa...
Efficacy was demonstrated in 3 short-term (24 hours of IM treatment) placebo-controlled trials in agitated adult inpatients with: schizophrenia or bipolar Idisorder (manic or mixed episodes) [seeClinical Studies] . “Psychomotor agitation” is defined in DSM-IV as “excessive motor activity associa...