The elimination half-life (t1/2尾) of olanzapine ranged from 27 to 38.6 hours in young healthy individuals.doi:10.2165/00003495-199753020-00007Bret FultonKaren L. GoaSpringer International PublishingDrugsFulton B, Goa KL. Olanzapine: a review of its pharmacological properties and therapeutic ...
Elimination half-life averaged 37.2 hours in this study.In geriatric patients, the mean elimination half-life of orally administered olanzapine was about 1.5 times that of younger patients.In women, clearance of olanzapine is approximately 30% lower than in men; there were no apparent differences ...
Geriatric— In a study involving 24 healthy subjects, the mean elimination half-life of olanzapine was about 1.5 times greater in elderly (≥65 years) than in nonelderly subjects (<65 years). Caution should be used in dosing the elderly, especially if there are other factors that might addit...
Olanzapine is extensively metabolised: at least 10 different metabolites, which appear to be inactive, have been identified. The elimination half-life (t1/2β) of olanzapine ranged from 27 to 38.6 hours in young healthy individuals. 展开 关键词:...
After one oral dose of 12mg in healthy adults, the peak concentration of serum drug was 11mg/L, and the final elimination half-life was 33 hours, and the plasma clearance rate was 18 to 27L/ hours. Sex, age and smoking status have some effects on the half-life and clearance rate ...
Their elimination half-life is about 75 h. They are mostly excreted in the urine and 20% in the feces. Mechanism of action The atypical antipsychotics mostly block receptors in the brain's dopamine pathways. In the olanzapine/fluoxetine combination drug, fluoxetine inhibits serotonin reu...
Because of the long elimination half-lives of fluoxetine and its major active metabolite, changes in dose will not be fully reflected in plasma for several weeks, affecting both strategies for titration to final dose and withdrawal from treatment; this is of potential consequence when drug discontin...
Zyprexa Relprevv (Olanzapine Extended Release Injectable Suspension) may treat, side effects, dosage, drug interactions, warnings, patient labeling, reviews, and related medications including drug comparison and health resources.
Osmotic minipumps were chosen as preferred mode of administration because the half-life of olanzapine is only 2½ h in rats compared to 30 h in humans. We discovered that, within one week, degradation of olanzapine occurred in the solution used to fill the minipump reservoir. This resulted...
Separation of olanzapine, carbamazepine and their main metabolites by capillary electrophoresis with pseudo-stationary phases.pdf 2015-05-30上传 Separation of olanzapine, carbamazepine and their main metabolites by capillary electrophoresis with pseudo-stationary phases ...