The elimination half-life of intramuscular olanzapine is 30–39 hours and may be increased in elderly recipients and women. Pharmacokinetic interactions may occur with drugs that affect the cytochrome P450 enzymes responsible for formation of olanzapine metabolites. Smoking can increase the clearance of ...
Geriatric— In a study involving 24 healthy subjects, the mean elimination half-life of olanzapine was about 1.5 times greater in elderly (≥65 years) than in nonelderly subjects (<65 years). Caution should be used in dosing the elderly, especially if there are other factors that might addit...
Geriatric— In a study involving 24 healthy subjects, the mean elimination half-life of olanzapine was about 1.5 times greater in elderly (≥65 years) than in nonelderly subjects (<65 years). Caution should be used in dosing the elderly, especially if there are other factors that might addit...
Pharmacoeconomic and Quality-of-Life Profile Pharmacoeconomic comparisons of olanzapine and placebo generally suggest that olanzapine does not add to the overall treatment cost of patients with bipolar I disorder, and may even furnish small cost savings. Among 139 patients with bipolar I disorder treat...
The atypical antipsychotics are also known as second-generation antipsychotics and serotonin-dopamine antagonists. They have 87% bioavailability and more than 99%protein binding. The atypical antipsychotics are metabolized in the liver, byCYP3A4andCYP2D6. Their elimination half-life is about ...
Osmotic minipumps were chosen as preferred mode of administration because the half-life of olanzapine is only 2½ h in rats compared to 30 h in humans. We discovered that, within one week, degradation of olanzapine occurred in the solution used to fill the minipump reservoir. This resulted...
Zyprexa Relprevv (Olanzapine Extended Release Injectable Suspension) may treat, side effects, dosage, drug interactions, warnings, patient labeling, reviews, and related medications including drug comparison and health resources.
This is the first report to measure serum prolactin levels in an olanzapine-overdosed toddler and the second to calculate olanzapine's elimination half-life.Tanoshima,R.Chandranipapongse,W.Colantonio,D.Stefan,C.Nulman,I.Therapeutic Drug Monitoring...
Olanzapine is an antipsychotic drug that belongs to the tienobenzodiacepine (group) with afinity for the dopaminergic, serotoninergic, adrenergic, histaminergic and muscarinic receptors and a half-life of elimination 30′5 hours. In the present work it's related an intoxication with 650 mg. of ...
(CYP) 1A2, CYP2D6 and the flavin mono-oxygenase-3 system, and is excreted mainly in the urine, with an elimination half-life of approximately 33 hours. The clearance of olanzapine is moderately reduced by inhibitors of CYP1A2 (fluvoxamine) and CYP2D6 (fluoxetine), and increased by potent ...