Olanzapine appears to be poorly tolerated in patients with Parkinson's disease, psychotic symptoms, and dementia.doi:10.1176/appi.psy.42.6.477Laura MarshConstantine LyketsosStephen G. ReichPsychosomaticsOlanzapine for the treatment of psychosis in patients with Parkinson’s disease and dementia. ...
Although no significant between-treatment differences were seen in efficacy for overall psychotic symptoms as assessed by changes from baseline in the PANSS or BPRS total score (fig. 3,table V), olanzapine demonstrated significantly greater improvements from baseline in measures of negative and depressiv...
Psychotic symptoms are a common complication in Parkinson's disease with dementia. The authors conducted an open-label 6-week trial of olanzapine preceded by a placebo lead-in in five subjects with Parkinson's disease, mild to moderately severe dementia, and psychosis. Four of the subjects termin...
Olanzapine is a favorable drug with a potential treatment of delirium, psychotic depression, mood disorders and nausea with a single drug in advanced cancer patients. Additional benefits include weight gain. The medication has few drug interactions, a narrow therapeutic window and high drug cost, whi...
Do I need a prescription for olanzapine? Yes WARNING Elderly patients withdementia insomnia, dry mouth, orthostatic hypotension, tremor, and weight gain. Several disorders of movement also may occur with olanzapine, for example, extrapyramidal effects (sudden, often jerky, involuntary motions of the ...
Olanzapine is not approved for the treatment of patients with dementia-related psychosis. (See Increased Mortality in Geriatric Patients with Dementia-related Psychosis in Boxed Warning.)SuicideAttendant risk with psychotic illness and bipolar disorder; closely supervise high-risk patients. Prescribe in th...
It has a high affinity for muscarinic (M-1) and adrenoceptors (alpha-1) View chapterExplore book Olanzapine Zoe Clarke, in xPharm: The Comprehensive Pharmacology Reference, 2007 Therapeutics Olanzapine is indicated in the management of the manifestations of psychotic disorders. Indications Empty Cell...
Olanzapine has efficacy for both positive and negative symptoms of schizophrenia, long-term maintenace treatment. Olanzapine also has efficacy for treatment refractory schizophrenia, schizoaffective disorder, schizophreniform disorder, bipolar disorder, substance induced psychotic disorder. Recommended doses ...
(clozapine,olanzapine,risperidone,quetiapine).Elderly individuals are at risk of developing side effects with any psychotropics.Olanzapine is commonly used for the management of psychotic symptoms as well as for the management of behavioural and psychological problems with dementia in the elderly.In this...
Olanzapine is not approved for the treatment of patients with dementia-related psychosis [see Warnings and Precautions (5.1), Use in Specific Populations (8.5), and Patient Counseling Information (17)]. When using olanzapine and fluoxetine in combination, also refer to the Boxed Warning section of...